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Decreased autophagy in salivary glands of primary Sjogren's syndrome patients could be associated with an increased expression of inflammatory markers
(BMJ PUBLISHING GROUP, 2019)
Sin resumen
Promoter dna methylation and HSA-MIR-424-5P regulate ATF6 alpha expression in salivary glands of patients with Sjogren's syndrome
(BMJ PUBLISHING GROUP, 2019)
Sin resumen
Tracing Mapuche Exclusion from Post-Dictatorial Truth Commissions in Chile: Official and Grassroots Initiatives
(OXFORD UNIV PRESS, 2018)
This article critically examines the official misrecognition of Mapuche experiences of violence during Augusto Pinochet's dictatorship (1973-1990) in state-sponsored truth commissions in Chile. We examine official ...
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjogren's syndrome patients
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)
Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) ...
Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro
(Oxford University Press, 2020-04)
Objectives. Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate ...
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjo¨gren's syndrome
(ELSEVIER, 2021-07-23)
Relevant reviews highlight the association between dysfunctional mitochondria and inflammation, but few studies address the contribution of mitochondria and mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) to ...
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjogren's syndrome
(OXFORD UNIV PRESS, 2021-05-25)
Objective. Altered homeostasis of salivary gland (SG) epithelial cells in Sjogren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important ...
Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjogren's Syndrome Patients
(FRONTIERS MEDIA SA, 2021-06-02)
Sjogren's syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients
(FRONTIERS MEDIA SA, 2023-03-23)
IntroductionPrimary Sjogren's syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular ...