Search

Now showing items 1-1 of 1

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis

Woehlbier, Ute [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Medinas, Danilo B.; Rozas, Pablo; Martínez Traub, Francisca; Brown, Robert H.; Bosco, Daryl A.; Hetz, Claudio (NATL ACAD SCIENCES, 2018)

Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...