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Mitochondria in Developmental and Adult Neurogenesis
(SPRINGER, 2019)
Generation of new neurons is a tightly regulated process that involves several intrinsic and extrinsic factors. Among them, a metabolic switch from glycolysis to oxidative phosphorylation, together with mitochondrial ...
Schwann cells are early and active participants of axonal degeneration
(WILEY, 2019)
Axonal degeneration in adult organisms is a common end point of several diseases leading to loss of neuronal function and circuit remodeling. It has been long assumed that axonal degeneration takes place by means of neuronal ...
Huntingtin and Rab27a are involved in the secretion of exosomes from astroglial cells.
(WILEY, 2019)
Sin resumen
Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019)
Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic degeneration are early and critical elements of nearly all human ...
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(BMC, 2019)
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment
(SPRINGER, 2019)
Heart failure (HF) is a major public health issue affecting more than 26 million people worldwide. HF is the most common cardiovascular disease in elder population; and it is associated with neurocognitive function decline, ...
Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System
(SPRINGER, 2019)
Autophagy is considered a major bulk degradation system that helps cells to counteract different intracellular and extracellular stress signals. Several protein complexes integrate multiple signals in order to activate ...
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)
BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ...