Recent Submissions

  • DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients and a Transgenic Model of the Disease 

    Leyton, Esteban [Chile. Universidad Mayor. Centro de Biología Integrativa]; Matus, Diego [Chile. Universidad Mayor. Centro de Biología Integrativa]; Espinoza, Sandra [Chile. Universidad Mayor. Centro de Biología Integrativa]; Benítez, José Matías [Chile. Universidad Mayor. Centro de Biología Integrativa]; Cortés, Bastián [Chile. Universidad Mayor. Centro de Biología Integrativa]; Gómez, Wileidy [Chile. Universidad Mayor. Centro de Biología Integrativa]; Arévalo, Nohela B. [Chile. Universidad Mayor. Centro de Biología Integrativa]; Murgas, Paola [Chile. Universidad Mayor. Centro de Biología Integrativa]; Manque Ramírez, Patricio [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Woehlbier, Ute [Chile. Universidad Mayor. Centro de Biología Integrativa]; Durán-Aniotz, Claudia; Hetz, Claudio; Behrens, María Isabel; San Martín, Carol D. [Chile. Universidad Mayor. Centro de Biología Integrativa]; Nassif, Melissa [Chile. Universidad Mayor. Centro de Biología Integrativa] (IOS Press, 2021-02-19)
    Background:Disturbances in the autophagy/endolysosomal systems are proposed as early signatures of Alzheimer’s disease (AD). However, few studies are available concerning autophagy gene expression in AD patients. Objective:To ...
  • Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis 

    Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Humana Press, 2018)
    Glial cells regulate a wide variety of neuronal functions during physiological and pathological conditions. Therefore, the study of glial cells and their association with axons is of paramount importance in order to ...
  • Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs 

    Gregorio, Cristian de [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Díaz, Paula [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; López-Leal, Rodrigo [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Manque, Patricio [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Humana Press, 2018)
    Exosomes are small (30-150 nm) vesicles of endosomal origin secreted by most cell types. Exosomes contain proteins, lipids, and RNA species including microRNA, mRNA, rRNA, and long noncoding RNAs. The mechanisms associated ...
  • In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia 

    López-Leal, Rodrigo [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Díaz, Paula [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Humana Press, 2018)
    Sensory neurons from dorsal root ganglion efficiently regenerate after peripheral nerve injuries. These neurons are widely used as a model system to study degenerative mechanisms of the soma and axons, as well as regenerative ...
  • A dual role for Integrin alpha 6 beta 4 in modulating hereditary neuropathy with liability to pressure palsies 

    Poitelon, Yannick; Matafora, Vittoria; Silvestri, Nicholas; Zambroni, Desiree; McGarry, Claire; Serghany, Nora; Rush, Thomas; Vizzuso, Domenica; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Bachi, Angela; Wrabetz, Lawrence; Feltri, María Laura (WILEY, 2018-05)
    Peripheral myelin protein 22 (PMP22) is a component of compact myelin in the peripheral nervous system. The amount of PMP22 in myelin is tightly regulated, and PMP22 over or under-expression cause Charcot-Marie-Tooth 1A ...
  • Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo 

    Krasnow, Anna M.; Ford, Marc C.; Valdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Wilson, Stephen W.; Attwell, David (NATURE PUBLISHING GROUP, 2018-01)
    How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high ...
  • The Enigmatic Role of C9ORF72 in Autophagy 

    Nassif, Melissa [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Woehlbier, Ute [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Manque, Patricio A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (FRONTIERS MEDIA SA, 2017-08-03)
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and ...
  • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates 

    García-Huerta, Paula; Troncoso-Escudero, Paulina Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Wu, Di; Thiruvalluvan, Arun; Cisternas-Olmedo, Marisol [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez-Billault, Christian; Bergink, Steven; Vidal, Rene L.; Hetz, Claudio (SPRINGER, 2020-11)
    Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
  • Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (vol 32, pg 274, 2019) 

    Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Salvadores, Natalia [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Martínez, Alexis; Moreno-González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz, Claudio; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Chile. Universidad Mayor, 2020-07)
    Correction to: Cell Death & Differentiation https://doi.org/10.1038/s41418-019-0408-4. Since online publication of this article, the authors noticed that reference details provided for references 65 and 66 were incorrect. ...
  • The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease 

    Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Salvadores, Natalia [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Martínez, Alexis; Moreno-González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz, Claudio; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (NATURE PUBLISHING GROUP, 2020-04)
    Parkinson's disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ...
  • Axonal Degeneration Is Mediated by Necroptosis Activation 

    Arrazola, Macarena S. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristián [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catalán, Romina J. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Barrientos, Sebastián A.; Hernández, Diego E.; Martínez, Nicolás W.; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (SOC NEUROSCIENCE, 2019-05-15)
    Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated ...
  • Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology 

    Arrazola, Macarena S. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2019-08)
    Sin resumen.
  • Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance 

    Cafferata, Emilio A.; Castro-Saavedra, Sebastián; Fuentes-Barros, Gonzalo; Melgar-Rodriguez, Samanta; Rivera, Felipe; Carvajal, Paola; Hernández, Marcela; Cortés, Bastian, I [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cassels, Bruce K.; Vernal, Rolando (Chile. Universidad Mayor, 2020-06)
    Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ...
  • Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes 

    Cordero, Esteban M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortes, Bastian I. [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Palominos, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Parra, Pedro [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Mella, Tania [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henrríquez, Constanza [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Salazar, Nelda [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Monasterio, Gustavo; Cafferata, Emilio A.; Murgas, Paola [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (MDPI, 2020-05)
    The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ...
  • IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis 

    Monasterio, Gustavo; Budini, Victoria; Fernández, Baltasar; Castillo, Francisca; Rojas, Carolina; Alvarez, Carla; Cafferata, Emilio A.; Vicencio, Emiliano [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortés, Bastian I. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando (Blackwell Munksgaard, 2019-10)
    Background and Objective Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that are ...
  • Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis 

    Moya-Alvarado G., Bronfman F.C.; Hernández, Diego E. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Salvadores, Natalia A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Catalán, Romina J. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Company of Biologists Ltd, 2018)
    Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma ...
  • MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content 

    Balboa E., Castro J., Pinochet M.-J., Matías N., José Sáez P., Martínez A., Álvarez A.R., Garcia-Ruiz C., Fernandez-Checa J.C., Zanlungo S.; Cancino, Gonzalo I. [Centro de Biología Integrativa, Universidad Mayor, Chile] (Elsevier BV, 2017)
    MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in ...
  • Herpes simplex virus type 1 neuronal infection perturbs golgi apparatus integrity through activation of src tyrosine kinase and Dyn-2 GTPase 

    Martin C., Leyton L., Hott M., Arancibia Y., Spichiger C., McNiven M.A., Concha M.I., Burgos P.V., Otth C.; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)
    Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown. ...
  • Axonal degeneration during aging and its functional role in neurodegenerative disorders 

    Salvadores, Natalia [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Sanhueza, Mario [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Manque, Patricio [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)
    Aging constitutes the main risk factor for the development of neurodegenerative diseases. This represents a major health issue worldwide that is only expected to escalate due to the ever-increasing life expectancy of the ...
  • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model 

    Bargsted L., Medinas D.B., Martínez Traub F., Rozas P., Muñoz N., Jerez C., Court F.A., Hetz C., Matus S.; Nassif, Melissa [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Catenaccio, Alejandra [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Nature Publishing Group, 2017)
    Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...

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