Listar por autor "González, María-Julieta"
Mostrando ítems 1-7 de 7
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Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro
Castro, Isabel; Albornoz, Nicolás; Aguilera, Sergio; Barrera, María-José; González, Sergio [Universidad Mayor, Chile]; Nuñez, Matilde; Carvajal, Patricia; Jara, Daniela; Lagos, Carolina; Molina, Claudio; Urzua, Ulises; Hermoso, Marcela A.; González, María-Julieta (Oxford University Press, 2020-04)Objectives. Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate ... -
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjogren's syndrome patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Lagos, Carolina; Caryajal, Patricia; Castro, Isabel; Jara, Daniela; Aguilera, Sergio; Barrera, María-José; Quest, Andrew F. G.; Bahamondes, Veronica; Molina, Claudio; Urzua, Ulises; Hermoso, Marcela A.; Leyton, Cecilia; González, María-Julieta (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) ... -
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogren's syndrome
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; González, María-Julieta (ELSEVIER SCIENCE BV, 2018)For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the importance of target ... -
Expression of JAK Proteins and Autophagy Markers in Sjogren's Syndrome Patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Molina, Claudio; Urzua, Ulises; González, María-Julieta (WILEY, 2018) -
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogren's syndrome patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Molina, Claudio [Univ Mayor, Fac Ciencias, Dept Patol Oral, Escuela Odontol, Santiago, Chile]; Sepúlveda, Denisse; Barrera, María-José; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; Albornoz, Nicolás; Bahamondes, Verónica; Quest, Andrew F. G.; Urzua, Ulises; Leyton, Cecilia; Hermoso, Marcela A.; González, María-Julieta (OXFORD UNIV PRESS, 2018)Objectives. Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1 alpha (IRE1 ... -
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients
Carvajal, Patricia; Bahamondes, Verónica; Jara, Daniela; Castro, Isabel; Matus, Soledad; Aguilera, Sergio; Molina, Claudio; González, Sergio [Univ Mayor, Escuela Odontol, Fac Med & Ciencias Salud, Chile]; Hermoso, Marcela; Barrera, María-José; González, María-Julieta (FRONTIERS MEDIA SA, 2023-03-23)IntroductionPrimary Sjogren's syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular ... -
Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjogren's Syndrome Patients
Jara, Daniela; Carvajal, Patricia; Castro, Isabel; Barrera, María-José; Aguilera, Sergio; Molina, Claudio; Hermoso, Marcela; González, María-Julieta; González, Sergio [Univ Mayor, Fac Ciencias, EScuela Odontol, Chile] (FRONTIERS MEDIA SA, 2021-06-02)Sjogren's syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...