Listar por autor "González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim]"
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Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach
González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim]; Soto-Alarcón, Sandra A.; Ortiz, Macarena; Orellana, Paula; Echeverria, Francisca; Bustamante, Andres; Espinosa, Alejandra; Illesca, Paola; Valenzuela, Rodrigo; Videla, Luis A. (WILEY, 2019)Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant ... -
High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration
González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim]; Echeverria, Francisca; Valenzuela, Rodrigo; Bustamante, Andres; Alvarez, Daniela; Ortiz, Macarena; Espinosa, Alejandra; Illesca, Paola; Videla, Luis A. (ROYAL SOC CHEMISTRY, 2019)High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial dysfunction. Our hypothesis is that the ... -
Iron-induced derangement in hepatic Delta-5 and Delta-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil
González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim]; Barrera, Cynthia; Valenzuela, Rodrigo; Rincon, Miguel A.; Espinosa, Alejandra; López-Arana, Sandra; Romero, Nalda; Vargas, Romina; Videla, Luis A. (ELSEVIER SCI LTD, 2020)The administration of iron induces liver oxidative stress and depletion of long-chain polyunsaturated fatty acids (LCPUFAs), n-6/n-3 LCPUFA ratio enhancement and fat accumulation, which may be prevented by antioxidant-rich ...