Listar por autor "Public Library of Science"
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Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss.
Calixto, Andrea [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Jara, Juan S. [Pontificia Universidad Católica de Chile. Facultad de Biología]; Court, Felipe A. [Pontificia Universidad Católica de Chile. Facultad de Biología] (Facultad de Ciencias, 2012)Axonal degeneration is a key event in the pathogenesis of neurodegenerative conditions. We show here that mec-4d triggered axonal degeneration of Caenorhabditis elegans neurons and mammalian axons share mechanistical ... -
Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
Kalempa Demeu, Lara Maria; Soares, Rodrigo Jahn; Miranda, Juliana Severo; Pacheco-Lugo, Lisandro A.; Oliveira, Kelin Goncalves; Cortez Plaza, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Billiald, Philippe; de Moura, Juliana Ferreira; Yoshida, Nobuko; Alvarenga, Larissa Magalhaes; DaRocha, Wanderson Duarte (Chile. Universidad Mayor, 2019-10-16)Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ... -
Ndae1 expression and regulation in Drosophila embryos
Tevy, María Florencia [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Seyres, Denis [Francia. Aix-Marseille Université]; Traina, Concetta [Italia. University of Ferrara]; Perrin, Laurent [Francia. Aix-Marseille Université]; Capovilla, María [Francia. Institut Sophia Agrobiotech] (Facultad de Ciencias, 2014)The construction and prediction of cell fate maps at the whole embryo level require the establishment of an accurate atlas of gene expression patterns throughout development and the identification of the corresponding ... -
The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains
Hernández-Guerrero, Rafael; Galán-Vásquez, Edgardo; Pérez-Rueda, Ernesto [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (Public Library of Science, 2019-12-19)In this work, we describe a systematic comparative genomic analysis of promiscuous domains in genomes of Bacteria and Archaea. A quantitative measure of domain promiscuity, the weighted domain architecture score (WDAS), ... -
Transcriptome analysis during ripening of table grape berry cv. Thompson Seedless
Balic, Iván [Chile. Universidad Andrés Bello, Facultad Ciencias Biológicas, Centro de Biotecnología Vegetal]; Vizoso, Paula [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Propagación y Conservación de Plantas - CEPROVEG]; Nilo Poyanco, Ricardo [Chile. FONDAP Centro de Regulación del Genoma]; Sanhueza, Dayan [Chile. Universidad Andrés Bello, Facultad Ciencias Biológicas, Centro de Biotecnología Vegetal]; Olmedo, Patricio [Chile. Universidad Andrés Bello, Facultad Ciencias Biológicas, Centro de Biotecnología Vegetal]; Sepúlveda, Pablo [Chile. Universidad Andrés Bello, Facultad Ciencias Biológicas, Centro de Biotecnología Vegetal]; Arriagada, César [Chile. Universidad de La Frontera. Facultad de Ciencias Agropecuarias y Forestales. Departamento de Ciencias Forestales. Laboratorio Biorremediación]; Defilippi, Bruno G. [Chile. Instituto de Investigaciones Agropecuarias - INIA]; Meneses, Claudio [Chile. Universidad Andrés Bello, Facultad Ciencias Biológicas, Centro de Biotecnología Vegetal]; Campos Vargas, Reinaldo [Chile. Universidad Andrés Bello, Facultad Ciencias Biológicas, Centro de Biotecnología Vegetal] (Chile. Universidad Mayor, 2018-01-10)Ripening is one of the key processes associated with the development of major organoleptic characteristics of the fruit. This process has been extensively characterized in climacteric fruit, in contrast with non-climacteric ...