Listar por autor "Westermeier, Francisco"
Mostrando ítems 1-4 de 4
-
Cytosolic phosphoenolpyruvate carboxykinase is expressed in alpha-cells from human and murine pancreas
Gatica, Rodrigo [Univ Mayor, Escuela Vet, Fac Ciencias, Santiago, Chile]; Westermeier, Francisco; Holyoak, Todd; Martínez, Fernando; Negron, Marianne; Yanez, Alejandro J.; Nahmias, Daniel; Nualart, Francisco; Burbulis, Ian; Bertinat, Romina (WILEY, 2020)The pancreatic islets of Langerhans, mainly formed by glucagon-producing alpha-cells and insulin-producing beta-cells, are critical for glucose homeostasis. Insulin and glucagon oppositely modulate blood glucose levels in ... -
Gluconeogenic Enzymes in beta-Cells: Pharmacological Targets for Improving Insulin Secretion
Gatica, Rodrigo [Univ Mayor, Fac Ciencias, Escuela Vet]; Westermeier, Francisco; Holyoak, Todd; Asenjo, Joel L.; Nualart, Francisco; Burbulis, Ian; Bertinat, Romina (ELSEVIER SCIENCE LONDON, 2019)Pancreatic beta-cells express the gluconeogenic enzymes glucose 6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBP), and phosphoenolpyruvate (PEP) carboxykinase (PCK), which modulate glucose-stimulated insulin secretion ... -
Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes?
Gatica, Rodrigo [Univ Mayor, Lab Patol Vet, Escuela Vet, Fac Ciencias, Santiago, Chile]; Bertinat, Romina; Westermeier, Francisco; Nualart, Francisco (WILEY, 2019)Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by pancreatic cells, the resistance of peripheral tissues to the action of the hormone, or both, and is characterized by chronic ... -
The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice
Gatica, Rodrigo [Univ Mayor, Fac Ciencias, Escuela Vet, Santiago, Chile]; Bertinat, Romina; Westermeier, Francisco; Silva, Pamela; Moitinho Oliveira, Joana; Nualart, Francisco; Gomis, Ramon; Yañez, Alejandro J. (HINDAWI LTD, 2018)The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal ...