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The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model
(OXFORD UNIV PRESS, 2018)Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset progressive neurodegenerative disease characterized by upper and lower motoneuron degeneration. A total of 20% of familial ALS (fALS) cases are explained by ... -
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients
(FRONTIERS MEDIA SA, 2023-03-23)IntroductionPrimary Sjogren's syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular ... -
The interaction of our genes with the obesogenic environment
(SOC MEDICA SANTIAGO, 2019)Sin resumen -
The joint association of sarcopenia and frailty with incidence and mortality health outcomes: A prospective study
(Churchill Livingstone, 2021-04)Background: Sarcopenia and frailty are strongly associated with disease incidence and mortality. However, there is limited evidence regarding their joint association with health outcomes. This study aimed to investigate ... -
The joint effect of sitting time and obesity on the odds of developing type 2 diabetes
(SOC MEDICA SANTIAGO, 2018)Background: Obesity and sedentary behavior are risk factors acting independently in the development of type 2 diabetes. Aim: To investigate whether the association between diabetes and obesity is modified by the levels of ... -
The levels, subcellular distribution and posttranslational processing of salivary mucins are affected
(CLINICAL & EXPER RHEUMATOLOGY, 2018) -
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling
(NATURE PUBLISHING GROUP, 2019)Pathogenic variants of OPA1, which encodes a dynamin GTPase involved in mitochondrial fusion, are responsible for a spectrum of neurological disorders sharing optic nerve atrophy and visual impairment. To gain insight on ... -
The Microbial Composition in Circumneutral Thermal Springs from Chignahuapan, Puebla, Mexico Reveals the Presence of Particular Sulfur-Oxidizing Bacterial and Viral Communities
(MDPI AG, 2020-11)Terrestrial thermal springs are widely distributed globally, and these springs harbor a broad diversity of organisms of biotechnological interest. In Mexico, few studies exploring this kind of environment have been described. ... -
The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging
(Frontiers Media S.A., 2020-09)Aging is the time-dependent functional decline that increases the vulnerability to different forms of stress, constituting the major risk factor for the development of neurodegenerative diseases. Dysfunctional mitochondria ... -
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
(NATURE PUBLISHING GROUP, 2020-04)Parkinson's disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ... -
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?
(Taylor and Francis Ltd., 2020-07)Introduction: Necroptosis is a programmed form of necrotic cell death. Growing evidence demonstrates that necroptosis contributes to cell demise in different pathological conditions including age-dependent neurodegenerative ... -
The negative effect of lianas on tree growth varies with tree species and seasonPalavras-chave
(Wiley-Blackwell, 2020-05)Lianas reduce tree growth, reproduction, and survival in tropical forests. Liana competition can be particularly intense in isolated forest fragments, where liana densities are high, and thus, host tree infestation is ... -
The Oculome Panel Test: Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders
(ELSEVIER SCIENCE INC, 2019)Purpose: To develop a comprehensive next-generation sequencing panel assay that screens genes known to cause developmental eye disorders and inherited eye disease and to evaluate its diagnostic yield in a pediatric cohort ... -
THE ORGANIZATIONAL CULTURE AND VALUES ALIGNMENT MANAGEMENT IMPORTANCE FOR SUCCESSFUL BUSINESS
(Chile. Universidad Mayor, 2017)The main objective of this study was to carry out an organizational culture diagnosis in a shipyard, verifying the alignment degree between personal and organizational values. For data collection, a structured questionnaire ... -
The origin and emplacement of Domo Tinto, Guallatiri volcano, Northern Chile.
(CIENCIAS, 2014)El volcán Guallatiri (18°25'S, 69°05'W) es un edificio volcánico ubicado en el Altiplano del norte de Chile, cercano a la frontera con Bolivia. Este volcán, construido en el Pleistoceno-Holoceno en el extremo sur de la ... -
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(BMC, 2019)The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...