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dc.contributorEscuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chilees
dc.contributorCentro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chilees
dc.contributorCentro de Nanotecnología Aplicada, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chilees
dc.contributor.authorSantos, Nicolás [Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]
dc.contributor.authorValenzuela, Santiago
dc.contributor.authorSegura, Camilo
dc.contributor.authorOsorio-Román, Igor
dc.contributor.authorArrázola, Macarena S. [Centro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]
dc.contributor.authorPanadero-Medianero, Concepción [Centro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]
dc.contributor.authorSantana, Paula A.
dc.contributor.authorAhumada, Manuel [Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]
dc.date.accessioned2024-02-24T20:53:30Z
dc.date.available2024-02-24T20:53:30Z
dc.date.issued2023-10-17
dc.identifier.citationSantos, N., Valenzuela, S., Segura, C., Osorio-Roman, I., Arrázola, M. S., Panadero-Medianero, C., Santana, P. A., & Ahumada, M. (2023). Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance. Discover nano, 18(1), 129. https://doi.org/10.1186/s11671-023-03907-4es
dc.identifier.issn2731-9229
dc.identifier.issn1931-7573
dc.identifier.otherPMID: 37847425
dc.identifier.otherSCOPUS_ID:85174406808
dc.identifier.urihttps://repositorio.umayor.cl/xmlui/handle/sibum/9454
dc.identifier.urihttps://doi.org/10.1186/s11671-023-03907-4
dc.identifier.urihttps://cnap.umayor.cl/publicaciones/poly-ethylene-imine-chitosan-carbon-dots-study-of-its-physical-chemical-properties-and-biological-in-vitro-performance
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10581970&blobtype=pdf
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581970/pdf/11671_2023_Article_3907.pdf
dc.identifier.urihttps://link.springer.com/article/10.1186/s11671-023-03907-4
dc.description.abstractCarbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties is not always accompanied by cytocompatibility. Thus, a knowledge gap exists regarding their interactions with biological systems linked to the selected formulations and synthesis methods. In this work, we have developed carbon dots (CDs) based on poly (ethylene imine) (PEI) and chitosan (CS) by using microwave irradiation, hydrothermal synthesis, and a combination of both, and further characterized them by physicochemical and biological means. Our results indicate that synthesized CDs have sizes between 1 and 5 nm, a high presence of amine groups on the surface, and increased positive ζ potential values. Further, it is established that the choice and use of different synthesis procedures can contribute to a different answer to the CDs regarding their optical and biological properties. In this regard, PEI-only CDs showed the longest photoluminescent emission lifetime, non-hemolytic activity, and high toxicity against fibroblast. On the other hand, CS-only CDs have higher PL emission, non-cytotoxicity associated with fibroblast, and high hemolytic activity. Interestingly, their combination using the proposed methodologies allow a synergic effect in their CDs properties. Therefore, this work contributes to developing and characterizing CD formulations based on PEI and CS and better understanding the CD's properties and biological interaction.es
dc.description.sponsorship11220120; 11170244 y 11180616 del Fondo Nacional de Desarrollo Científico y Tecnológico.es
dc.format.extent14 p., PDFes
dc.language.isoenes
dc.publisherSpringer New Yorkes
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees
dc.titlePoly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performancees
dc.typeArtículo o Paperes
umayor.indizadorCOTes
umayor.indexadoScopuses
umayor.indexadoPUBMEDes
dc.identifier.doi10.1186/S11671-023-03907-4
umayor.indicadores.wos-(cuartil)Q1
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 131
umayor.indicadores.scopus-(scimago-sjr)SJR 1


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