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El Repositorio Institucional de la Universidad Mayor, tiene como objetivo publicar, en formato digital, todos los objetos derivados de su producción científica, académica, cultural y artística. En palabras simples es una vitrina que pone en valor su patrimonio documental.
Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing ...
Arrazola, Macarena S. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristián [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catalán, Romina J. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Barrientos, Sebastián A.; Hernández, Diego E.; Martínez, Nicolás W.; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile](SOC NEUROSCIENCE, 2019-05-15)
Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated ...
Court, Felipe A [Chile. Universidad Mayor]; Hetz, Claudio [Estados Unidos. Harvard University](CIENCIAS, 2016)
Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system (PNS) is damaged. These pathological state are are associated with weakness, pain, and loss of motor and sensory control. More ...
Oñate, Maritza [Chile. Universidad Mayor]; Hetz, Claudio [Universidad de Chile]; Court, Felipe A [Chile. Universidad Mayor](CIENCIAS, 2016)
Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex ...
Moya-Alvarado G., Bronfman F.C.; Hernández, Diego E. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Salvadores, Natalia A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Catalán, Romina J. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile](Company of Biologists Ltd, 2018)
Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma ...
Salvadores, Natalia [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Sanhueza, Mario [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Manque, Patricio [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile](Frontiers Media S.A., 2017)
Aging constitutes the main risk factor for the development of neurodegenerative diseases. This represents a major health issue worldwide that is only expected to escalate due to the ever-increasing life expectancy of the ...
Sanhueza, Mario [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Mueller, Marioly; Ahumada-Castro, Ulises; González-Billault, Christian; Cárdenas, César(FRONTIERS MEDIA SA, 2018)
Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several age-dependent neurodegenerative diseases and may be a major contributing factor in ...
Vidal, Rene L. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Rivera, Claudia A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Urra, Hery; Henriquez, Daniel R.; Canovas, José; Villarroel-Campos, David; Carreras-Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Alvarez-Rojas, Sebastián; Figueroa, Ricardo; Rodríguez, Diego A.; Couve, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic, Alvaro; González-Billault, Christian; Hetz, Claudio(NATURE PUBLISHING GROUP, 2018)
Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
Richards, Natalie [Wolfson Centre for Age-Related Diseases, Kings College London, London,United Kingdom]; Schmid, Annina B. [University of Oxford, Oxford. Nuffield Department of Clinical Neurosciences]; Barroso, Alejandro [Reino Unido. Wolfson Centre for Age-Related Diseases]; Zhu, Lan [Reino Unido. Wolfson Centre for Age-Related Diseases]; Ivulic, Dinka [Pontificia Universidad Católica de Chile]; Zhu, Ning [Reino Unido. University of Oxford. Nuffield Department of Clinical Neurosciences]; Anwandter, Philipp [Pontificia Universidad Católica de Chile]; Manzoor, Bhat A. [Estados Unidos. UT Health Science Center at San Antonio](CIENCIAS, 2016)
Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of ...
Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...
