Mostrando ítems 81-85 de 85

    • Injury to the nervous system: A look into the ER 

      Oñate, Maritza [Chile. Universidad Mayor]; Hetz, Claudio [Universidad de Chile]; Court, Felipe A [Chile. Universidad Mayor] (CIENCIAS, 2016)
      Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex ...
    • Bursting the unfolded protein response accelerates axonal regeneration 

      Court, Felipe A [Chile. Universidad Mayor]; Hetz, Claudio [Estados Unidos. Harvard University] (CIENCIAS, 2016)
      Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system (PNS) is damaged. These pathological state are are associated with weakness, pain, and loss of motor and sensory control. More ...
    • Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury 

      Richards, Natalie [Wolfson Centre for Age-Related Diseases, Kings College London, London,United Kingdom]; Schmid, Annina B. [University of Oxford, Oxford. Nuffield Department of Clinical Neurosciences]; Barroso, Alejandro [Reino Unido. Wolfson Centre for Age-Related Diseases]; Zhu, Lan [Reino Unido. Wolfson Centre for Age-Related Diseases]; Ivulic, Dinka [Pontificia Universidad Católica de Chile]; Zhu, Ning [Reino Unido. University of Oxford. Nuffield Department of Clinical Neurosciences]; Anwandter, Philipp [Pontificia Universidad Católica de Chile]; Manzoor, Bhat A. [Estados Unidos. UT Health Science Center at San Antonio] (CIENCIAS, 2016)
      Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of ...
    • Schwann cell and axon: An interlaced unit—From action potential to phenotype expression 

      Court, Felipe A. [Chile. Universidad Mayor. Center for Integrative Biology]; Alvarez, Jaime [Pontificia Universidad Católica de Chile. Millenium Nucleus for Regenerative Biology] (Facultad de Ciencias, 2016)
      Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence ...
    • Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration 

      Catenaccio, Alejandra [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]; Díaz, Paula [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]; Lamont, Douglas J. [Reino Unido. University of Dundee. School of Life Sciences]; Wishart, Thomas M. [Reino Unido. University of Edinburgh. The Roslin Institute]; Hurtado, Maica Llavero [Reino Unido. University of Edinburgh. The Roslin Institute]; Court, Felipe A. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa] (Chile. Universidad Mayor, 2017-11)
      Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for ...


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