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Sjogren's syndrome and the epithelial target: A comprehensive review
The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with the ...
Oral dryness in Sjogren's syndrome patients: Not just a question of water
Sjögren's syndrome (SS) is a chronic autoimmune disease of undefined etiology. Patients with this syndrome suffer from severe alterations in both the quality and quantity of saliva and tears, due to impaired function of ...
Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome: association with mononuclear cell infiltration
Objective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjögren’s syndrome, and to relate ...
Oral manifestations and their treatment in Sjogren's syndrome
Sjögren's syndrome (SS) is a complex, chronic, systemic, autoimmune disease that mainly affects the exocrine glands, especially the salivary and lacrimal glands, leading to dryness of the oral and ocular mucosae. Several ...
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome
Objectives: To evaluate the expression and localization of MUC1/SEC and MUC1/Y isoforms in labial salivary glands (LSG) from Sjögren's syndrome patients (SS patients), as well as their in vitro expression induced by ...
Severe alterations in expression and localisation of alpha 6 beta 4 integrin in salivary gland acini from patients with Sjogren syndrome
Objectives: In salivary glands from patients with Sjogren syndrome, overexpression of laminins 1 and 5 and disorganisation of the acinar basal lamina have been reported. Laminin 5 mediates association of the basal lamina ...