Listar INVESTIGACIÓN por autor "Brooks, Matthew D."
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ConnecTF: A platform to integrate transcription factor-gene interactions and validate regulatory networks
Brooks, Matthew D.; Juang, Che-Lun; Katari, Manpreet Singh; Pasquino, Angelo; Shih, Hung-Jui; Huang, Ji; Shanks, Carly; Cirrone, Jacopo; Coruzzi, Gloria M.; Alvarez, Jose M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile] (OXFORD UNIV PRESS INC, 2021-04-28)Deciphering gene regulatory networks (GRNs) is both a promise and challenge of systems biology. The promise lies in identifying key transcription factors (TFs) that enable an organism to react to changes in its environment. ... -
Nitrate in 2020: Thirty Years from Transport to Signaling Networks
Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Alvarez, Jose M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Araus, Viviana; Riveras, Eleodoro; Brooks, Matthew D.; Krouk, Gabriel; Ruffel, Sandrine; Lejay, Laurence; Crawford, Nigel M.; Coruzzi, Gloria M.; Gutierrez, Rodrigo A. (American Society of Plant Biologists, 2020-07)Nitrogen (N) is an essential macronutrient for plants and a major limiting factor for plant growth and crop production. Nitrate is the main source of N available to plants in agricultural soils and in many natural environments. ... -
Time-Based Systems Biology Approaches to Capture and Model Dynamic Gene Regulatory Networks
Alvarez, Jose M.; Brooks, Matthew D.; Swift, Joseph; Coruzzi, Gloria M.; Alhafez, Iyad Alabd [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (ANNUAL REVIEWS, 2021-07-19)All aspects of transcription and its regulation involve dynamic events. However, capturing these dynamic events in gene regulatory networks (GRNs) offers both a promise and a challenge. The promise is that capturing and ... -
Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade
Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Schinke, Anna-Lena; Brooks, Matthew D.; Pasquino, Angelo; Leonelli, Lauriebeth; Varala, Kranthi; Safi, Alaeddine; Krouk, Gabriel; Krapp, Anne; Coruzzi, Gloria M. (Nature Publishing Group, 2020-03-02)Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly respond to environmental perturbation. However, the underlying transient interactions between transcription factors (TFs) and genome-wide ...