Listar INVESTIGACIÓN por autor "Carvajal, Patricia"
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Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro
Castro, Isabel; Albornoz, Nicolás; Aguilera, Sergio; Barrera, María-José; González, Sergio [Universidad Mayor, Chile]; Nuñez, Matilde; Carvajal, Patricia; Jara, Daniela; Lagos, Carolina; Molina, Claudio; Urzua, Ulises; Hermoso, Marcela A.; González, María-Julieta (Oxford University Press, 2020-04)Objectives. Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate ... -
Decreased autophagy in salivary glands of primary Sjogren's syndrome patients could be associated with an increased expression of inflammatory markers
González, Sergio [Univ Mayor, Escuela Odontol, Santiago, Chile]; Barrera, Maria-Jose; Aguilera, Sergio; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; Molina, Claudio; Matus, Soledad; González, Maria-Julieta (BMJ PUBLISHING GROUP, 2019)Sin resumen -
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjo¨gren's syndrome
Barrera, Maria-Jose; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Jara, Daniela; Molina, Claudio; Gonzalez, Maria-Julieta; Gonzalez, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile] (ELSEVIER, 2021-07-23)Relevant reviews highlight the association between dysfunctional mitochondria and inflammation, but few studies address the contribution of mitochondria and mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) to ... -
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogren's syndrome
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; González, María-Julieta (ELSEVIER SCIENCE BV, 2018)For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the importance of target ... -
Expression of JAK Proteins and Autophagy Markers in Sjogren's Syndrome Patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Molina, Claudio; Urzua, Ulises; González, María-Julieta (WILEY, 2018) -
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogren's syndrome patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Molina, Claudio [Univ Mayor, Fac Ciencias, Dept Patol Oral, Escuela Odontol, Santiago, Chile]; Sepúlveda, Denisse; Barrera, María-José; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; Albornoz, Nicolás; Bahamondes, Verónica; Quest, Andrew F. G.; Urzua, Ulises; Leyton, Cecilia; Hermoso, Marcela A.; González, María-Julieta (OXFORD UNIV PRESS, 2018)Objectives. Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1 alpha (IRE1 ... -
Promoter dna methylation and HSA-MIR-424-5P regulate ATF6 alpha expression in salivary glands of patients with Sjogren's syndrome
González, Sergio [Univ Mayor, Escuela Odontol, Santiago, Chile]; Carvajal, Patricia; Aguilera, Sergio; Barrera, Maria-Jose; Lagos, Carolina; Castro, Isabel; Jara, Daniela; Molina, Claudio; González, Maria-Julieta (BMJ PUBLISHING GROUP, 2019)Sin resumen -
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients
Carvajal, Patricia; Bahamondes, Verónica; Jara, Daniela; Castro, Isabel; Matus, Soledad; Aguilera, Sergio; Molina, Claudio; González, Sergio [Univ Mayor, Escuela Odontol, Fac Med & Ciencias Salud, Chile]; Hermoso, Marcela; Barrera, María-José; González, María-Julieta (FRONTIERS MEDIA SA, 2023-03-23)IntroductionPrimary Sjogren's syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular ... -
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjogren's syndrome
Barrera, Maria-Jose; Aguilera, Sergio; Castro, Isabel; Matus, Soledad; Carvajal, Patricia; Molina, Claudio; Jara, Daniela; Hermoso, Marcela; Gonzalez, Maria-Julieta; Gonzalez, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Chile] (OXFORD UNIV PRESS, 2021-05-25)Objective. Altered homeostasis of salivary gland (SG) epithelial cells in Sjogren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important ... -
Tofacitinib Inhibits Increased Inflammatory Marker Expression in a Human Salivary Cell Line Deficient in Autophagy: A Model of Sjogren's Syndrome
González, Sergio [Univ Mayor, Escuela Odontol, Santiago, Chile]; JoséBarrera, Maria; Aguilera, Sergio; Carvajal, Patricia; Castro, Isabel; Molina, Claudio; Matus, Soledad; Jara, Daniela; Julieta González, Maria (WILEY, 2019)Sin resumen -
Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjogren's Syndrome Patients
Jara, Daniela; Carvajal, Patricia; Castro, Isabel; Barrera, María-José; Aguilera, Sergio; Molina, Claudio; Hermoso, Marcela; González, María-Julieta; González, Sergio [Univ Mayor, Fac Ciencias, EScuela Odontol, Chile] (FRONTIERS MEDIA SA, 2021-06-02)Sjogren's syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...