Listar INVESTIGACIÓN por autor "Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]"
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Axonal degeneration during aging and its functional role in neurodegenerative disorders
Salvadores, Natalia [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Sanhueza, Mario [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Manque, Patricio [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)Aging constitutes the main risk factor for the development of neurodegenerative diseases. This represents a major health issue worldwide that is only expected to escalate due to the ever-increasing life expectancy of the ... -
Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis
Moya-Alvarado G., Bronfman F.C.; Hernández, Diego E. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Salvadores, Natalia A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Catalán, Romina J. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Company of Biologists Ltd, 2018)Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma ... -
Herpes simplex virus type 1 neuronal infection perturbs golgi apparatus integrity through activation of src tyrosine kinase and Dyn-2 GTPase
Martin C., Leyton L., Hott M., Arancibia Y., Spichiger C., McNiven M.A., Concha M.I., Burgos P.V., Otth C.; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown. ...