Listar INVESTIGACIÓN por autor "Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]"
Mostrando ítems 1-4 de 4
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IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
Vidal, Rene L. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Rivera, Claudia A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Urra, Hery; Henriquez, Daniel R.; Canovas, José; Villarroel-Campos, David; Carreras-Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Alvarez-Rojas, Sebastián; Figueroa, Ricardo; Rodríguez, Diego A.; Couve, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic, Alvaro; González-Billault, Christian; Hetz, Claudio (NATURE PUBLISHING GROUP, 2018)Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ... -
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
Sanhueza, Mario [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Mueller, Marioly; Ahumada-Castro, Ulises; González-Billault, Christian; Cárdenas, César (FRONTIERS MEDIA SA, 2018)Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several age-dependent neurodegenerative diseases and may be a major contributing factor in ... -
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model
Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; González, David; Rebolledo, Daniela L.; Correa, Lina M.; Cerpa, Waldo; Lipson, Kenneth E.; van Zundert, Brigitte; Brandan, Enrique (OXFORD UNIV PRESS, 2018)Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset progressive neurodegenerative disease characterized by upper and lower motoneuron degeneration. A total of 20% of familial ALS (fALS) cases are explained by ... -
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Pérez, Viviana; Bermedo-Garcia, Francisca; Zelada, Diego; Angel Pérez, Miguel; Fuenzalida, Marco; Abrigo, Johanna; Cabello-Verrugio, Claudio; Moya-Alvarado, Guillermo; Carlos Tapia, Juan; Valenzuela, Vicente; Hetz, Claudio; Bronfman, Francisca C.; Pablo Henríquez, Juan (BMC, 2019)The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...