Listar INVESTIGACIÓN por autor "Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]"
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Axonal Degeneration in AD: The Contribution of A beta and Tau
Salvadores, Natalia [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Geronimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Frontiers Media S.A., 2020-10)Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder, affecting around 35 million people worldwide. Despite enormous efforts dedicated to AD research over decades, there is still no ... -
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile
Lemaitre, Dominique; Llavero Hurtado, Maica; De Gregorio, Cristian; Onate, Maritza; Martínez, Gabriela; Catenaccio, Alejandra [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Wishart, Thomas M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Humana Press, 2020-10)Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered by compensatory or regenerative processes. In situations where axonal regeneration of injured neurons is hampered, compensation by ... -
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain
Gorostieta-Salas, Elisa; Moreno-Blas, Daniel; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cisneros, Bulmaro; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castro-Obregón, Susana (HINDAWI LTD, 2021-08-16)Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such ... -
GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly
Slachevsky, Andrea; Zitko, Pedro; Martínez-Pernia, David; Forno, Gonzalo; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lillo, Patricia; Villagra, Roque; Durán-Aniotz, Claudia; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibañez, Agustín; Parra, Mario A.; Gonzalez-Billault, Christian; Amieva, Helena; Thumala, Daniela (BioMed Central Ltd., 2020-12)BackgroundWith the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and ... -
Metformin protects from oxaliplatin induced peripheral neuropathy in rats
Martinez, N W [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Sánchez, A.; Diaz, P.; Broekhuizen, R.; Godoy, J.; Mondaca, S.; Catenaccio, A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Macanas, P.; Nervi, B.; Calvo, M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Elsevier BV, 2020-08)Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients ... -
Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth
López-Leal, Rodrigo [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Díaz-Viraque, Florencia; Catalán, Romina J. [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Saquel, Cristian [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Enright, Anton; Iraola, Gregorio [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Company of Biologists Ltd, 2020-06)Functional recovery after peripheral nerve damage is dependent on the reprogramming of differentiated Schwann cells (dSCs) into repair Schwann cells (rSCs), which promotes axonal regeneration and tissue homeostasis. ... -
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?
Salvadores, Natalia [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Taylor and Francis Ltd., 2020-07)Introduction: Necroptosis is a programmed form of necrotic cell death. Growing evidence demonstrates that necroptosis contributes to cell demise in different pathological conditions including age-dependent neurodegenerative ...