Listar INVESTIGACIÓN por autor "Elorza, Alvaro A."
Mostrando ítems 1-2 de 2
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CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity 1 of 1 CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity
Briceño, Pedro; Rivas-Yañez, Elizabeth; Rosemblatt, Mariana V.; Parra-Tello, Brian; Vargas, Leonardo; Lladser, Alvaro; Salazar-Onfray, Flavio; Elorza, Alvaro A.; Rosemblatt, Mario; Bono, Maria Rosa; Sauma, Daniela; Farias, Paula; Cardenas, Cesar [Univ Mayor, Ctr Integrat Biol, Chile] (FRONTIERS MEDIA SA, 2021-02-18)CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ... -
Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics
Gonzalez-Ibanez, Alvaro M.; Ruíz, Lina M.; Jensen, Erik; Echeverria, Cesar A.; Romero, Valentina [Univ Mayor, Fac Ciencias, Ctr Nanotecnol Aplicada, Chile]; Stiles, Linsey; Shirihai, Orian S.; Elorza, Alvaro A. (Frontiers Media S.A., 2020-11)Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of similar to 2 x 10(11) cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid ...