• Pleione: A tool for statistical and multi-objective calibration of Rule-based models 

      Martin, Alberto J. M. [Univ Mayor, Fac Ciencias, Network Biol Lab, Ctr Genom & Bioinformat]; Santibáñez, Rodrigo [Univ Mayor, Fac Ciencias, Network Biol Lab, Ctr Genom & Bioinformat]; Garrido, Daniel (NATURE PUBLISHING GROUP, 2019)
      Mathematical models based on Ordinary Differential Equations (ODEs) are frequently used to describe and simulate biological systems. Nevertheless, such models are often difficult to understand. Unlike ODE models, Rule-Based ...
    • Stochastic simulation of multiscale complex systems with PISKaS: A rule-based approach 

      Martín, Alberto J. M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Pérez-Acle, Tomás; Fuenzalida, Ignacio; Santibañez, Rodrigo; Avaria, Rodrigo; Bernardin, Alejandro; Bustos, Alvaro M.; Garrido, Daniel; Dushoff, Jonathan; Liu, James H. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)
      Computational simulation is a widely employed methodology to study the dynamic behavior of complex systems. Although common approaches are based either on ordinary differential equations or stochastic differential equations, ...


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