Listar INVESTIGACIÓN por autor "Hermoso, Marcela"
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The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients
Carvajal, Patricia; Bahamondes, Verónica; Jara, Daniela; Castro, Isabel; Matus, Soledad; Aguilera, Sergio; Molina, Claudio; González, Sergio [Univ Mayor, Escuela Odontol, Fac Med & Ciencias Salud, Chile]; Hermoso, Marcela; Barrera, María-José; González, María-Julieta (FRONTIERS MEDIA SA, 2023-03-23)IntroductionPrimary Sjogren's syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular ... -
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjogren's syndrome
Barrera, Maria-Jose; Aguilera, Sergio; Castro, Isabel; Matus, Soledad; Carvajal, Patricia; Molina, Claudio; Jara, Daniela; Hermoso, Marcela; Gonzalez, Maria-Julieta; Gonzalez, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Chile] (OXFORD UNIV PRESS, 2021-05-25)Objective. Altered homeostasis of salivary gland (SG) epithelial cells in Sjogren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important ... -
Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjogren's Syndrome Patients
Jara, Daniela; Carvajal, Patricia; Castro, Isabel; Barrera, María-José; Aguilera, Sergio; Molina, Claudio; Hermoso, Marcela; González, María-Julieta; González, Sergio [Univ Mayor, Fac Ciencias, EScuela Odontol, Chile] (FRONTIERS MEDIA SA, 2021-06-02)Sjogren's syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...