Listar INVESTIGACIÓN por autor "Hernández, Marcela"
Mostrando ítems 1-5 de 5
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Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance
Cafferata, Emilio A.; Castro-Saavedra, Sebastián; Fuentes-Barros, Gonzalo; Melgar-Rodriguez, Samanta; Rivera, Felipe; Carvajal, Paola; Hernández, Marcela; Cortés, Bastian, I [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cassels, Bruce K.; Vernal, Rolando (Chile. Universidad Mayor, 2020-06)Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ... -
Gingival Crevicular Fluid Zinc- and Aspartyl-Binding Protease Profile of Individuals with Moderate/Severe Atopic Dermatitis
Valenzuela, Fernando; Fernández, Javier; Aroca, Marcela; Jiménez, Constanza; Albers Busquetts, Daniela [Univ Mayor, Dept Stat, Fac Dent, Chile]; Hernández, Marcela; Fernández, Alejandra (Chile. Universidad Mayor, 2020)Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD. We explored the ... -
Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia
Chaparro, Alejandra; Monckeberg, Maximiliano; Realini, Ornella; Hernández, Marcela; Param, Fernanda; Ramírez, Valeria; Kusanovic, Juan; Romero, Roberto; Rice, Gregory; Illanes, Sebastian E.; Albers, Daniela [Univ Mayor, Fac Dent, Dept Stat, Chile] (MDPI, 2021-05-13)Early and innovative diagnostic strategies are required to predict the risk of developing pre-eclampsia (PE). The purpose of this study was to evaluate the performance of gingival crevicular fluid (GCF) placental alkaline ... -
Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
Cafferata, Emilio A.; Terraza-Aguirre, Claudia; Barrera, Romina; Faúndez, Nicolás; González, Nicolás; Rojas, Carolina; Melgar-Rodríguez, Samanta; Hernández, Marcela; Carvajal, Paola; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; González, Fermin E.; Covarrubias, Cristian; Vernal, Rolando (Blackwell Munksgaard, 2020-04)Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ... -
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus
Albers, Daniela [Univ Mayor, Fac Dent, Dept Stat, Santiago, Chile]; Chaparro, Alejandra; Zuniga, Edgardo; Varas-Godoy, Manuel; Ramírez, Valeria; Hernández, Marcela; Kusanovic, Juan Pedro; Acuña-Gallardo, Stephanie; Rice, Gregory; Illanes, Sebastián E. (WILEY, 2018)Background: Gestational diabetes mellitus (GDM) affects around 7% to 10% of all pregnancies. Early detection of predisposition to GDM is the first step in developing efficacious preventive treatment. The objective of the ...