Listar INVESTIGACIÓN por autor "Quest, Andrew F. G."
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Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjogren's syndrome patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Lagos, Carolina; Caryajal, Patricia; Castro, Isabel; Jara, Daniela; Aguilera, Sergio; Barrera, María-José; Quest, Andrew F. G.; Bahamondes, Veronica; Molina, Claudio; Urzua, Ulises; Hermoso, Marcela A.; Leyton, Cecilia; González, María-Julieta (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) ... -
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogren's syndrome patients
González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Molina, Claudio [Univ Mayor, Fac Ciencias, Dept Patol Oral, Escuela Odontol, Santiago, Chile]; Sepúlveda, Denisse; Barrera, María-José; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; Albornoz, Nicolás; Bahamondes, Verónica; Quest, Andrew F. G.; Urzua, Ulises; Leyton, Cecilia; Hermoso, Marcela A.; González, María-Julieta (OXFORD UNIV PRESS, 2018)Objectives. Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1 alpha (IRE1 ...