• Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach 

      González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim]; Soto-Alarcón, Sandra A.; Ortiz, Macarena; Orellana, Paula; Echeverria, Francisca; Bustamante, Andres; Espinosa, Alejandra; Illesca, Paola; Valenzuela, Rodrigo; Videla, Luis A. (WILEY, 2019)
      Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant ...
    • Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration 

      González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim, Santiago, Chile]; Barrera, Cynthia; Valenzuela, Rodrigo; Angel Rincón, Miguel; Espinosa, Alejandra; Echeverria, Francisca; Romero, Nalda; Videla, Luis A. (ELSEVIER SCIENCE INC, 2018)
      Enhanced iron levels in liver are associated with oxidative stress development and damage with increased fat accumulation. The aim of this work was to assess the hypothesis that antioxidant-rich extra virgin olive oil ...
    • Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis 

      Calixto, Andrea [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Lima, Tanes I.; Guimaraes, Dimitrius Santiago P. S. F.; Oliveira, Andre G.; Araujo, Hygor; Sponton, Carlos H. G.; Souza-Pinto, Nadja C.; Saito, Angela; Figueira, Ana Carolina M.; Palameta, Soledad; Bajgelman, Marcio Chaim; Pinto, Silas; Mori, Marcelo A.; Orofino, Joey; Perissi, Valentina; Mottis, Adrienne; Auwerx, Johan; Silveira, Leonardo Reis (ELSEVIER SCIENCE INC, 2019)
      The ability to respond to fluctuations of reactive oxygen species (ROS) within the cell is a central aspect of mammalian physiology. This dynamic process depends on the coordinated action of transcriptional factors to ...


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