Now showing items 1-7 of 7

    • Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjogren's syndrome patients 

      González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Lagos, Carolina; Caryajal, Patricia; Castro, Isabel; Jara, Daniela; Aguilera, Sergio; Barrera, María-José; Quest, Andrew F. G.; Bahamondes, Veronica; Molina, Claudio; Urzua, Ulises; Hermoso, Marcela A.; Leyton, Cecilia; González, María-Julieta (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)
      Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) ...
    • Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogren's syndrome 

      González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; González, María-Julieta (ELSEVIER SCIENCE BV, 2018)
      For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the importance of target ...
    • Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis 

      Calixto, Andrea [Univ Mayor, Ctr Genom & Bioinformat, Fac Sci, Santiago, Chile]; Dubois-Camacho, Karen; Díaz-Jimenez, David; De la Fuente, Marjorie; Quera, Rodrigo; Simian, Daniela; Martínez, Maripaz; Landskron, Glauben; Olivares-Morales, Mauricio; Cidlowski, John A.; Xu, Xiaojiang; Gao, Guangping; Xie, Jun; Chnaiderman, Jonas; Soto-Rifo, Ricardo; González, Maria-Julieta; Hermoso, Marcela A. (FRONTIERS MEDIA SA, 2019)
      Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators ...
    • Intestinal epithelial cell-specific RAR alpha depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system 

      De Calisto, J. [Univ Mayor, Dent Sch, Ctr Genom & Bioinformat, Fac Sci, Santiago, Chile]; Jijon, H. B.; Suárez-López, L.; Díaz, O. E.; Das, S.; Yaffe, M. B.; Pittet, M. J.; Mora, J. R.; Belkaid, Y.; Xavier, R. J.; Villablanca, E. J. (NATURE PUBLISHING GROUP, 2018)
      Retinoic acid (RA), a dietary vitamin A metabolite, is crucial in maintaining intestinal homeostasis. RA acts on intestinal leukocytes to modulate their lineage commitment and function. Although the role of RA has been ...
    • Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system (vol 12, pg 580, 2019) 

      De Calisto, J. [Univ Mayor, Sch Dent, Ctr Genom & Bioinformat, Fac Sci, Santiago, Chile]; Jijon, H. B.; Suarez-López, L.; Díaz, O. E.; Das, S.; Parada-Kusz, M.; Yaffe, M. B.; Pittet, M. J.; Mora, J. R.; Belkaid, Y.; Xavier, R. J.; Villablanca, E. J.; Parada-kusz, Margarita (NATURE PUBLISHING GROUP, 2019)
      Sin resumen
    • Non-lysosomal Activation in Macrophages of Atlantic Salmon (Salmo salar) After Infection With Piscirickettsia salmonis 

      Reyes-Cerpa, Sebastián [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Valdés, Jorge [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Ibaceta, Valentina [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Brianson, Bernardo [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Espinoza, Allison [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Ahumada, Diego E. [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Tapia, Sebastián [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Pérez-Stuardo, Diego [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Morales-Reyes, Jonathan; Espinoza, Allison; Soto-Herrera, Valentina; Sandino, Ana M.; Spencer, Eugenio; Vallejos-Vidal, Eva; Reyes-López, Felipe E. (FRONTIERS MEDIA SA, 2019)
      Piscirickettsia salmonis is a facultative intracellular pathogen and etiological agent of the systemic disease salmonid rickettsial septicemia. It has been suggested that P salmonis is able to survive in host macrophages, ...
    • Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients 

      González, Sergio [Univ Mayor, Fac Ciencias, Escuela Odontol, Santiago, Chile]; Cortés, Juan; Hidalgo, Jorge; Aguilera, Sergio; Castro, Isabel; Brito, Monica; Urra, Hery; Pérez, Paola; Barrera, Maria-Jose; Carvajal, Patricia; Urzua, Ulises; Molina, Claudio; Bahamondes, Veronica; Hermoso, Marcela; González, Maria-Julieta (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019)
      Sjogren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...