ListarINVESTIGACIÓN por tema "Neurosciences"
Mostrando ítems 1-14 de 14
-
Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019)Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic degeneration are early and critical elements of nearly all human ... -
Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus
(SPRINGER, 2020)Alzheimer's disease (AD) is a devastating neurodegenerative disorder in which superior brain functions, such as memory and cognition, are impaired. Currently, no effective treatment is available for AD. Although andrographolide ... -
Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System
(SPRINGER, 2019)Autophagy is considered a major bulk degradation system that helps cells to counteract different intracellular and extracellular stress signals. Several protein complexes integrate multiple signals in order to activate ... -
ER Proteostasis Control of Neuronal Physiology and Synaptic Function
(ELSEVIER SCIENCE LONDON, 2018)Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) serves as a fundamental ... -
Huntingtin and Rab27a are involved in the secretion of exosomes from astroglial cells.
(WILEY, 2019)Sin resumen -
Inverse Relationship Between Alzheimer's Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases
(IOS PRESS, 2020)Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the adult population. There is evidence of an inverse epidemiological relationship between AD and cancer, another prevalent age-related disease. ... -
MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology
(FRONTIERS MEDIA SA, 2018)Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including ... -
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
(FRONTIERS MEDIA SA, 2018)Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several age-dependent neurodegenerative diseases and may be a major contributing factor in ... -
Mitochondria in Developmental and Adult Neurogenesis
(SPRINGER, 2019)Generation of new neurons is a tightly regulated process that involves several intrinsic and extrinsic factors. Among them, a metabolic switch from glycolysis to oxidative phosphorylation, together with mitochondrial ... -
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ... -
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment
(SPRINGER, 2019)Heart failure (HF) is a major public health issue affecting more than 26 million people worldwide. HF is the most common cardiovascular disease in elder population; and it is associated with neurocognitive function decline, ... -
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
(NATURE PUBLISHING GROUP, 2018)How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high ... -
Schwann cells are early and active participants of axonal degeneration
(WILEY, 2019)Axonal degeneration in adult organisms is a common end point of several diseases leading to loss of neuronal function and circuit remodeling. It has been long assumed that axonal degeneration takes place by means of neuronal ... -
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(BMC, 2019)The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...