Buscar
Mostrando ítems 421-430 de 439
Ernesto Neto (Río de Janeiro, 1964)
(Chile. Universidad Mayor, 2019-04)
Durante algunas semanas del verano pasado europeo, un árbol tejido de grandes dimensiones se suspendió de uno de los espacios más concurridos de Zúrich: la estación central de trenes. Esta obra se titula «Gaiamothertree», ...
Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2019-08)
Sin resumen.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
(NATURE PUBLISHING GROUP, 2019)
RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 ...
IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis
(Blackwell Munksgaard, 2019-10)
Background and Objective Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that are ...
The Oculome Panel Test: Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders
(ELSEVIER SCIENCE INC, 2019)
Purpose: To develop a comprehensive next-generation sequencing panel assay that screens genes known to cause developmental eye disorders and inherited eye disease and to evaluate its diagnostic yield in a pediatric cohort ...
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
(CELL PRESS, 2019)
Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing ...
Axonal Degeneration Is Mediated by Necroptosis Activation
(SOC NEUROSCIENCE, 2019-05-15)
Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated ...
Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits
(PUBLIC LIBRARY SCIENCE, 2019)
Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in ...
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)
BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ...
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells
(TAYLOR & FRANCIS INC, 2019)
The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent AMPK-dependent macroautophagic/autophagic flux, which is not ...