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Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjogren's syndrome patients
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)
Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) ...
Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro
(Oxford University Press, 2020-04)
Objectives. Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate ...
Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjogren's Syndrome Patients
(FRONTIERS MEDIA SA, 2021-06-02)
Sjogren's syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients
(FRONTIERS MEDIA SA, 2023-03-23)
IntroductionPrimary Sjogren's syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular ...