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Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjo¨gren's syndrome
(ELSEVIER, 2021-07-23)
Relevant reviews highlight the association between dysfunctional mitochondria and inflammation, but few studies address the contribution of mitochondria and mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) to ...
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjogren's syndrome
(OXFORD UNIV PRESS, 2021-05-25)
Objective. Altered homeostasis of salivary gland (SG) epithelial cells in Sjogren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important ...
Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjogren's Syndrome Patients
(FRONTIERS MEDIA SA, 2021-06-02)
Sjogren's syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...