Recent Submissions

  • The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains 

    Hernández-Guerrero, Rafael; Galán-Vásquez, Edgardo; Pérez-Rueda, Ernesto [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (Public Library of Science, 2019-12-19)
    In this work, we describe a systematic comparative genomic analysis of promiscuous domains in genomes of Bacteria and Archaea. A quantitative measure of domain promiscuity, the weighted domain architecture score (WDAS), ...
  • Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar) 

    Vallejos-Vidal, Eva; Reyes-Cerpa, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Maisey, Kevin; Yañez, José M.; Valenzuela, Héctor; Cea, Pablo A.; Castro-Fernández, Víctor; Tort, Lluis; Sandino, Ana M.; Imarai, Mónica; Reyes-López, Felipe E. (Frontiers Media S.A., 2020-02-27)
    Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ...
  • Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis 

    Cafferata, Emilio A.; Terraza-Aguirre, Claudia; Barrera, Romina; Faúndez, Nicolás; González, Nicolás; Rojas, Carolina; Melgar-Rodríguez, Samanta; Hernández, Marcela; Carvajal, Paola; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; González, Fermin E.; Covarrubias, Cristian; Vernal, Rolando (Blackwell Munksgaard, 2020-04)
    Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ...
  • Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus 

    Vergara, Eva; Neira, Gonzalo; González, Carolina [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Diego; Dopson, Mark; Holmes, David S. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (MDPI Multidisciplinary Digital Publishing Institute, 2020-04)
    Organisms that thrive in extremely acidic environments (<= pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely ...
  • A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues 

    Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Li, Yong; Martonfalvi, Zsolt; Tapia-Rojo, Rafael; Unger, Andreas; Fernández-Trasancos, Angel; Herrero-Galán, Elías; Velázquez-Carreras, Diana; Fernández, Julio M.; Linke, Wolfgang A.; Alegre-Cebollada, Jorge (Nature Publishing Group, 2020-04-28)
    Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ...
  • Draft Genome Sequence of Blautia luti DSM 14534(T), Isolated from Human Stool 

    Ortiz, Rodrigo L.; Melis-Arcos, Felipe; Covarrubias, Paulo C.; Ugalde, Juan A.; Apte, Zachary S.; Pérez-Donoso, José; Cárdenas, Juan P. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Almonacid, Daniel E. (Chile. Universidad Mayor, 2020-05)
    Here, we report the draft sequence of Blautia luti strain DSM 14534T, originally isolated from human feces. This draft contains 74 contigs, comprising 3,718,760 bp with a G+C content of 42.87%. The annotated draft contains ...
  • Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance 

    Cafferata, Emilio A.; Castro-Saavedra, Sebastián; Fuentes-Barros, Gonzalo; Melgar-Rodriguez, Samanta; Rivera, Felipe; Carvajal, Paola; Hernández, Marcela; Cortés, Bastian, I [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cassels, Bruce K.; Vernal, Rolando (Chile. Universidad Mayor, 2020-06)
    Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ...
  • Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes 

    Cordero, Esteban M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortes, Bastian I. [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Palominos, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Parra, Pedro [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Mella, Tania [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henrríquez, Constanza [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Salazar, Nelda [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Monasterio, Gustavo; Cafferata, Emilio A.; Murgas, Paola [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (MDPI, 2020-05)
    The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ...
  • Nutrient dose-responsive transcriptome changes driven by Michaelis Menten kinetics underlie plant growth rates 

    Swift, Joseph; Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Araus, Viviana; Gutiérrez, Rodrigo A.; Coruzzi, Gloria M. (National Academy of Sciences, 2020-06-09)
    An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes ...
  • Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade 

    Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Schinke, Anna-Lena; Brooks, Matthew D.; Pasquino, Angelo; Leonelli, Lauriebeth; Varala, Kranthi; Safi, Alaeddine; Krouk, Gabriel; Krapp, Anne; Coruzzi, Gloria M. (Nature Publishing Group, 2020-03-02)
    Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly respond to environmental perturbation. However, the underlying transient interactions between transcription factors (TFs) and genome-wide ...
  • A balancing act: how plants integrate nitrogen and water signals 

    Araus, Viviana; Swift, Joseph; Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henry, Amelia; Coruzzi, Gloria M. (Oxford University Press, 2020-07-25)
    Nitrogen (N) and water (W) are crucial inputs for plant survival as well as costly resources for agriculture. Given their importance, the molecular mechanisms that plants rely on to signal changes in either N or W status ...
  • IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis 

    Monasterio, Gustavo; Budini, Victoria; Fernández, Baltasar; Castillo, Francisca; Rojas, Carolina; Alvarez, Carla; Cafferata, Emilio A.; Vicencio, Emiliano [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortés, Bastian I. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando (Blackwell Munksgaard, 2019-10)
    Background and Objective Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that are ...
  • Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion 

    Kalempa Demeu, Lara Maria; Soares, Rodrigo Jahn; Miranda, Juliana Severo; Pacheco-Lugo, Lisandro A.; Oliveira, Kelin Goncalves; Cortez Plaza, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Billiald, Philippe; de Moura, Juliana Ferreira; Yoshida, Nobuko; Alvarenga, Larissa Magalhaes; DaRocha, Wanderson Duarte (Chile. Universidad Mayor, 2019-10-16)
    Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ...
  • Metagenome sequencing of the microbial community of a solar saltern crystallizer pond at C�huil Lagoon, Chile 

    Plominsky A.M., Delherbe N., Allen E.E., Blanchet M., Ikeda P., Santiba�ez F., Hanselmann K., Ulloa O., De la Iglesia R., von Dassow P., Astorga M., G�lvez M.J., Gonz�lez M.L., Henr�quez-Castillo C., Vaulot D., do Santos A.L., van den Engh G., Gimpel C., Bertoglio F., Delgado Y., Docmac F., Elizondo-Patrone C., Narv�ez S., Sorroche F.; Ugalde, Juan A. [Facultad de Ciencias, Universidad Mayor, Chile]; Rojas-Herrera, Marcelo [Facultad de Ciencias, Universidad Mayor, Chile]; Trefault, Nicole [Facultad de Ciencias, Universidad Mayor, Chile] (American Society for Microbiology, 2014)
    Cáhuil Lagoon in central Chile harbors distinct microbial communities in various solar salterns that are arranged as interconnected ponds with increasing salt concentrations. Here, we report the metagenome of the 3.0- to ...
  • Genome sequence of Vibrio VPAP30, isolated from an episode of massive mortality of reared larvae of scallop Argopecten purpuratus 

    Rojas R., Miranda C.D., Asenjo F.; Romero, Jaime [Centro de Genómica y Bioinformatica, Facultad de Ciencias, Universidad Mayor, Chile]; Valderrama, Katherinne [Microbial Pathogenesis & Vaccinol Res Grp, ‎Facultad de Ciencias, Universidad Mayor, Chile]; Segovia, Cristopher [Microbial Pathogenesis & Vaccinol Res Grp, ‎Facultad de Ciencias, Universidad Mayor, Chile]; Ugalde, Juan A. [Centro de Genómica y Bioinformatica, Facultad de Ciencias, Universidad Mayor, Chile]; Santander, Javier [Microbial Pathogenesis & Vaccinol Res Grp, ‎Facultad de Ciencias, Universidad Mayor, Chile] (American Society for Microbiology, 2015)
    We report here the 5.167-Mbp draft genome sequence of Vibrio VPAP30, isolated from an Argopecten purpuratus larval culture. Vibrio VPAP30 is the etiological agent of a vibriosis outbreak causing a complete collapse of a ...
  • Complete genome sequence of Salmonella enterica serovar Enteritidis bacteriophage f18SE, isolated in Chile 

    Robeson J.; Segovia, Cristopher [Microbial Pathogenesis & Vaccinol Lab, Facultad de Ciencias, Universidad Mayor, Chile]; Vásquez, Ignacio [Microbial Pathogenesis & Vaccinol Lab, Facultad de Ciencias, Universidad Mayor, Chile]; Maracaja-Coutinho, Vinicius [Centro de Genómica y Bioinformatica, Lab Integrat Bioinformat, Facultad de Ciencias, Universidad Mayor, Chile]; Santander, Javier [Microbial Pathogenesis & Vaccinol Lab, Facultad de Ciencias, Universidad Mayor, Chile] (American Society for Microbiology, 2015)
    Bacteriophage f18SE was isolated from poultry sewage in Olmue, Chile, and lytic activity was demonstrated against Salmonella enterica serovar Enteritidis and serovar Pullorum strains. This bacteriophage has a 41,868-bp ...
  • Efectividad de la simulación en la educación médica desde la perspectiva de seguridad de pacientes 

    Moya R. P., Ruz A. M., Froes M. P.; Parraguez López, Elisa [Escuela de Odontología, Facultad de Ciencias, Universidad Mayor, Chile]; Carreño E., Verónica [Escuela de Odontología, Facultad de Ciencias, Universidad Mayor, Chile]; Rodríguez C., Ana María [Escuela de Odontología, Facultad de Ciencias, Universidad Mayor, Chile] (Sociedad Médica de Santiago, 2017)
    We herein review the association between patients’ safety and simulation methods for medical education. This evidence should help to change the present paradigm in medical education, where there is still reticence towards ...
  • Guías basadas en la evidencia para el uso de traqueostomía en el paciente crítico 

    Raimondi N., Vial M.R., Calleja J., Quintero A., Celis E., Pacheco C., Ugarte S., Añón J.M., Hernández G., Vidal E., Chiappero G., Ríos F., Castilleja F., Matos A., Rodriguez E., Antoniazzi P., Teles J.M., Dueñas C., Sinclair J., Martínez L., Von der Osten I., Vergara J., Jiménez E., Arroyo M., Rodriguez C., Torres J., Fernandez-Bussy S., Nates J.L.; Cortés, Alban A. [Clínica Mayor de Temuco, Hospital de Nueva Imperial, Universidad Mayor, Chile] (Ediciones Doyma, S.L., 2017)
    Objetivos: Proporcionar guías de traqueostomía para el paciente crítico, basadas en la evidencia científica disponible, y facilitar la identificación de áreas en las cuales se requieren mayores estudios. Métodos: Un grupo ...
  • Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults [Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena] 

    Petermann F., Villagrán M., Troncoso C., Mardones L., Leiva A.M., Martínez M.A., Garrido-Méndez A., Poblete-Valderrama F., Salas-Bravo C., Ramírez-Vélez R., Ulloa N., Pérez-Bravo F.; Celis-Morales, Carlos [CIFE, Universidad Mayor, Chile] (Sociedad Médica de Santiago, 2018)
    Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and ...
  • Herpes simplex virus type 1 neuronal infection perturbs golgi apparatus integrity through activation of src tyrosine kinase and Dyn-2 GTPase 

    Martin C., Leyton L., Hott M., Arancibia Y., Spichiger C., McNiven M.A., Concha M.I., Burgos P.V., Otth C.; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)
    Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown. ...

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