• Metformin protects from oxaliplatin induced peripheral neuropathy in rats 

      Martinez, N W [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Sánchez, A.; Diaz, P.; Broekhuizen, R.; Godoy, J.; Mondaca, S.; Catenaccio, A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Macanas, P.; Nervi, B.; Calvo, M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Elsevier BV, 2020-08)
      Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients ...
    • Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth 

      López-Leal, Rodrigo [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Díaz-Viraque, Florencia; Catalán, Romina J. [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Saquel, Cristian [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Enright, Anton; Iraola, Gregorio [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Company of Biologists Ltd, 2020-06)
      Functional recovery after peripheral nerve damage is dependent on the reprogramming of differentiated Schwann cells (dSCs) into repair Schwann cells (rSCs), which promotes axonal regeneration and tissue homeostasis. ...


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