Listar Artículos SCOPUS por autor "Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile"
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Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria
Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Ahumada-Castro, Ulises [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Farias, Paula [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Gonzalez-Billault, Christian [Univ Mayor, Fac Sci, Gerosci Ctr Brain Hlth & Metab, Chile]; Molgo, Jordi; Cardenas, Cesar [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Frontiers Media S.A., 2020-05)Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca(2+)regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously ... -
Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer
Zhang, Yu; Chandra, Vidhi; Riquelme Sanchez, Erick [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Dutta, Prasanta; Quesada, Pompeyo R.; Rakoski, Amanda; Zoltan, Michelle; Arora, Nivedita; Baydogan, Seyda; Horne, William; Burks, Jared; Xu, Hanwen; Hussain, Perwez; Wang, Huamin; Gupta, Sonal; Maitra, Anirban; Bailey, Jennifer M.; Moghaddam, Seyed J.; Banerjee, Sulagna; Sahin, Ismet; Bhattacharya, Pratip; McAllister, Florencia (Rockefeller University Press, 2020-12)Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive ... -
Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction
Alvizi, Lucas; Nani, Diogo; Brito, Luciano Abreu; Kobayashi, Gerson Shigeru; Passos-Bueno, Maria Rita; Mayor, Roberto [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Nature Publishing Group, 2023-05-24)Gene-environment interactions are believed to play a role in multifactorial phenotypes, although poorly described mechanistically. Cleft lip/palate (CLP), the most common craniofacial malformation, has been associated with ... -
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells
Pérez-Moreno, Pablo; Quezada-Meza, Camila; Chavez-Almarza, Cristopher; Niechi, Ignacio; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Trigo-Hidalgo, César; Aguayo, Francisco; Jara, Lilian; Cáceres-Verschae, Albano; Varas-Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Veronica A.; Tapia, Julio C. (Frontiers Media S.A., 2020-07)Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ... -
SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells
Krabbendam, Inge E.; Honrath, Birgit; Bothof, Laura; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Huerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Penaranda Fajardo, Natalia M.; Dekker, Frank; Schmidt, Martina; Culmsee, Carsten; Cardenas, César Julio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Kruyt, Frank; Dolga, Amalia M. (Elsevier Inc., 2020-01)Brain tumours are among the deadliest tumours being highly resistant to currently available therapies. The proliferative behaviour of gliomas is strongly influenced by ion channel activity. Small-conductance calcium-activated ...