Listar Doctorado en Neurobiología por título
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Aging-associated H3K9 trimethylation reduces the mitochondrial unfolded protein response capacity leading to neurodegeneration and functional impairment of the olfactory system
(Chile. Universidad Mayor, 2022)Aging is one of the main risk factors for the onset and severity of neurodegenerative diseases. Progressive accumulation of dysfunctional mitochondria is particularly harmful in post-mitotic cells such as neurons, contributing ... -
Loss of the protein tyrosine phosphatase PTPRD induces increase in gabaergic and glutamatergic neurons in the cortex and impairs synaptic function, contributing to autistic-like behaviors
(Chile. Universidad Mayor, 2023-08)El trastorno del espectro autista se reconoce como un desorden del neurodesarrollo que se caracteriza por la aparición de déficits en la sociabilidad, la comunicación y comportamientos repetitivos y estereotipados. Si bien ... -
Role of IGF2 on inflammatory response in Parkinson's models
(Chile. Universidad Mayor, 2023)Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor deficits. α-Synuclein (α-syn) aggregates and neuroinflammation are hallmarks of PD, but the underlying ... -
Role of insulin-like growth factor 2 in degradation and secretion of alpha-synuclein and its impact in dopaminergic neuron survival in Parkinson’s disease models
(Chile. Universidad Mayor, 2024)La enfermedad de Parkinson (EP) es el segundo trastorno neurodegenerativo más común después de la enfermedad de Alzheimer (EA). Está caracterizado por la pérdida de neuronas dopaminérgicas (DAérgicas) en una región específica, ...