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Municipal police support for harm reduction services in officer-led referrals of people who inject drugs in Tijuana, Mexico
(BMC, 2021-08-01)
Background Police constitute a structural determinant of health and HIV risk of people who inject drugs (PWID), and negative encounters with law enforcement present significant barriers to PWID access to harm reduction ...
Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort
(IOS PRESS, 2021-07-15)
Background: Amyloid-beta peptide (A beta) deposition in Alzheimer's disease (AD) is due to an imbalance in its production/clearance rate. Ap is transported across the blood-brain barrier by LRP1 and P-gp as efflux transporters ...
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjo¨gren's syndrome
(ELSEVIER, 2021-07-23)
Relevant reviews highlight the association between dysfunctional mitochondria and inflammation, but few studies address the contribution of mitochondria and mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) to ...
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjogren's syndrome
(OXFORD UNIV PRESS, 2021-05-25)
Objective. Altered homeostasis of salivary gland (SG) epithelial cells in Sjogren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important ...
Hypoxic Respiratory Chemoreflex Control in Young Trained Swimmers
(FRONTIERS MEDIA SA, 2021-03-29)
During an apnea, changes in PaO2 activate peripheral chemoreceptors to increase respiratory drive. Athletes with continuous apnea, such as breath-hold divers, have shown a decrease in hypoxic ventilatory response (HVR), ...
School Memories of Preservice Teachers: An Analysis of Their Role in the Conceptions About the Relationships Between Emotions and Teaching/Learning Processes
(FRONTIERS MEDIA SA, 2021-10-13)
With the aim of exploring the role of emotional elementary school memories that preservice teachers have, in their conceptions about the relationships between emotions and teaching-learning processes, a study was carried ...
Parental care in male degus (Octodon degus) is flexible and contingent upon female care
(PERGAMON-ELSEVIER SCIENCE LTD, 2021-09-01)
Parents in many animal species provide care to their offspring as a mechanism to enhance their own fitness. In mammals, this behavior is expressed mostly by the females, but also by males of some species. Proximally, rates ...
Sensitivity of Water Price Elasticity Estimates to Different Data Aggregation Levels
(SPRINGER, 2021-05-13)
The empirical literature on residential water demand employs various data aggregation methods, which depend on whether the aggregation is over consumption, sociodemographic variables, or both. In this study, we distinguish ...
Development of "on-demand" thermo-responsive hydrogels for anti-cancer drugs sustained release: Rational design, in silico prediction and in vitro validation in colon cancer models
(ELSEVIER, 2021-12)
A rational design accurate based on the use of Statistical Design of the Experiments (DoE) and Molecular Dynamics Simulations Studies allows the prediction and the understanding of thermo-responsive hydrogels prepared ...
Home-based exercise programmes improve physical fitness of healthy older adults: A PRISMA-compliant systematic review and meta-analysis with relevance for COVID-19
(ELSEVIER IRELAND LTD, 2021-04-19)
This systematic review and meta-analysis aimed to examine the effects of home-based exercise programmes on measures of physical-fitness in healthy older adults. Seventeen randomized-controlled trials were included with a ...