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Mitochondria in Developmental and Adult Neurogenesis
(SPRINGER, 2019)
Generation of new neurons is a tightly regulated process that involves several intrinsic and extrinsic factors. Among them, a metabolic switch from glycolysis to oxidative phosphorylation, together with mitochondrial ...
Schwann cells are early and active participants of axonal degeneration
(WILEY, 2019)
Axonal degeneration in adult organisms is a common end point of several diseases leading to loss of neuronal function and circuit remodeling. It has been long assumed that axonal degeneration takes place by means of neuronal ...
Huntingtin and Rab27a are involved in the secretion of exosomes from astroglial cells.
(WILEY, 2019)
Sin resumen
Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019)
Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic degeneration are early and critical elements of nearly all human ...
MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology
(FRONTIERS MEDIA SA, 2018)
Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including ...
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(BMC, 2019)
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment
(SPRINGER, 2019)
Heart failure (HF) is a major public health issue affecting more than 26 million people worldwide. HF is the most common cardiovascular disease in elder population; and it is associated with neurocognitive function decline, ...
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
(NATURE PUBLISHING GROUP, 2018)
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high ...
Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus
(SPRINGER, 2020)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder in which superior brain functions, such as memory and cognition, are impaired. Currently, no effective treatment is available for AD. Although andrographolide ...
ER Proteostasis Control of Neuronal Physiology and Synaptic Function
(ELSEVIER SCIENCE LONDON, 2018)
Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) serves as a fundamental ...