• Login
    View Item 
    •   DSpace Home
    • INVESTIGACIÓN
    • Artículos SCOPUS
    • View Item
    •   DSpace Home
    • INVESTIGACIÓN
    • Artículos SCOPUS
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    El Repositorio Institucional de la Universidad Mayor, tiene como objetivo publicar, en formato digital, todos los objetos derivados de su producción científica, académica, cultural y artística. En palabras simples es una vitrina que pone en valor su patrimonio documental.


    InformaciónInicioAcerca deFormulariosManuales

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    xmlui.EPerson.Navigation.loginxmlui.EPerson.Navigation.register

    Schwann cell and axon: An interlaced unit—From action potential to phenotype expression

    Thumbnail
    Date
    2016
    Author

    Court, Felipe A. [Chile. Universidad Mayor. Center for Integrative Biology]

    Alvarez, Jaime [Pontificia Universidad Católica de Chile. Millenium Nucleus for Regenerative Biology]

    Geographic location

    Note
    Tools
    Cite
    Vea como citar este artículo

    Show full item record
    Abstract
    Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence in several fields and show that (i) axons can extend sprouts and grow without the concurrence of the cell body, but regulated by SCs; (ii) axons synthesize their proteins assisted by SCs that supply them with ribosomes and, probably, with mRNAs by way of exosomes; (iii) the molecular organization of the axoplasm, i.e., its phenotype, is regulated by the SC, as illustrated by the axonal microtubular content, which is down-regulated by the SC; and (iv) the axon has a program for self-destruction that is boosted by the SC. The main novelty of this model axon-SC unit is that it breaks with the notion that all proteins of the nerve cell are specified by its own nucleus. The notion of a collaborative specification of the axoplasm by more than one nucleus, which we present here, opens a new dimension in the understanding of the nervous system in health and disease and is also a frame of reference to understand other tissues or cell associations.
    URI
    http://repositorio.umayor.cl/xmlui/handle/sibum/2595
    https://link.springer.com/chapter/10.1007/978-3-319-40764-7_9
    https://doi.org/10.1007/978-3-319-40764-7_9
    Collections
    • Artículos SCOPUS

    Si usted es autor(a) de este documento y NO desea que su publicación tenga acceso público en este repositorio, por favor complete el formulario aquí.


    Contact Us | Send Feedback
    Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
    DSpace software copyright © 2002-2018  DuraSpace
     

     



    Contact Us | Send Feedback
    Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
    DSpace software copyright © 2002-2018  DuraSpace