| dc.contributor | LIPPINCOTT WILLIAMS & WILKINS | es_CL |
| dc.contributor.author | Chinchon, Eduardo [Chile. Universidad Mayor] | es_CL |
| dc.contributor.author | Morales, Danny [Chile. Universidad Mayor] | es_CL |
| dc.contributor.author | Stehberg, Jimmy [Chile. Universidad Andrés Bello] | es_CL |
| dc.contributor.author | Simon, Felipe [Chile. Universidad Andrés Bello] | es_CL |
| dc.date.accessioned | 2018-09-07T13:04:16Z | |
| dc.date.available | 2018-09-07T13:04:16Z | |
| dc.date.issued | 2012 | es_CL |
| dc.identifier.citation | Tapia, P., Chinchón, E., Morales, D., Stehberg, J., & Simon, F. (2012). Effectiveness of short-term 6-hour high-volume hemofiltration during refractory severe septic shock. Journal of Trauma and Acute Care Surgery, 72(5), 1228-1238. | es_CL |
| dc.identifier.issn | ISSN 2163-0755 | es_CL |
| dc.identifier.issn | ESSN 2163-0763 | es_CL |
| dc.identifier.uri | https://journals.lww.com/jtrauma/Abstract/2012/05000/Effectiveness_of_short_term_6_hour_high_volume.14.aspx | es_CL |
| dc.identifier.uri | https://doi.org/10.1097/TA.0b013e318248bc6c | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/2674 | |
| dc.description.abstract | BACKGROUND: The effectiveness of a single 6-hour session of high-volume hemofiltration (HVHF) was evaluated in terms of decreased norepinephrine (NE) requirements, progressive refractory hypotension and hypoperfusion by the fourth hour, and observed versus expected hospital mortality in patients with refractory severe septic shock. METHODS: A prospective cohort study conducted at the intensive care unit with 31 patients suffering from severe septic shock (NE dose >= 0.3 mu g(.)kg(-1.)min(-1) to maintain mean arterial pressure 70-80 mm Hg and lactic acidosis) and refractory to treatments recommended by Surviving Sepsis Campaign, 2008. All patients were subjected to a single short-term 6-hour HVHF with a goal-directed protocol. Changes in NE dose, hemodynamic, metabolic, and respiratory parameters were measured at the onset (t(0)), 4 (t(4)) and 6 hours (t(6)) during HVHF. Patients were considered responders if by t4 of HVHF, they showed a decrease in NE dose >= 50%, maintaining mean arterial pressure 80 mm Hg to 70 mm Hg. RESULTS: Twenty-five of the 31 patients responded to HVHF treatment (responders), whereas 6 did not (nonresponders). In the responders group, a decrease in NE dose was observed by t4 (1.3 +/- 0.5 mu gkg(-1.)min(-1)). This beneficial effect was maintained by t6 of treatment. Hemodynamic, metabolic, and respiratory parameters and other organic function indicators were also significantly improved by t4 and maintained by t6. Hospital mortality (45.16%) was significantly lower than that predicted by Sequential Organ Failure Assessment score (>90%): 83% for nonresponders versus 36% for responders. CONCLUSIONS: We conclude that a single session of short-term 6-hour HVHF in patients with refractory severe septic shock reduces NE dose requirements and improves organic function already by the fourth hour of treatment. | es_CL |
| dc.description.sponsorship | Este trabajo no contó con financiamiento. | es_CL |
| dc.format.extent | ARTÍCULO ORIGINAL | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | CIENCIAS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es_CL |
| dc.subject | CIENCIAS DE LA SALUD | es_CL |
| dc.title | Effectiveness of short-term 6-hour high-volume hemofiltration during refractory severe septic shock | es_CL |
| dc.type | Artículo o Paper | es_CL |
| umayor.indizador | COT | es_CL |
| umayor.politicas.sherpa/romeo | Licencia color: AMARILLO (Puede archivar el pre-print (ie la versión previa a la revisión por pares))--Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares) Post-print del autor: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares) siempre que se cumplan las restricciones: 12 meses de embargo Versión de editor/PDF: cross el autor no puede archivar la versión del editor/PDF. Condiciones generales: Algunas revistas tienen políticas independientes, consultar directamente con cada revista, El pre-print debe retirarse al ser aceptado para su publicación, Post-print may be deposited in personal website or institutional repository, La versión de editor/PDF no puede utilizarse, Debe incluirse declaración de que no se trata de la versión publicada, La fuente publicada debe reconocerse con la cita completa, La declaración establecida debe acompañar el depósito, Debe ir enlazado a la versión de editor, NIH authors will have their accepted manuscripts transmitted to PubMed Central on their behalf after a 12 months embargo (see policy for details), Wellcome Trust and HHMI authors will have their accepted manuscripts transmitted to PubMed Central on their behalf after a 6 months embargo (see policy for details), RCUK authors articles will be released as Creative Commons Attribution Non-Commercial No Derivatives after 6 months// Disponible en: http://www.sherpa.ac.uk/romeo/issn/2163-0755/es/ | es_CL |
| umayor.indexado | WOS | es_CL |
| umayor.indexado | SCOPUS | es_CL |
| dc.identifier.doi | 10.1097/TA.0b013e318248bc6c | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q2 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | sin información | es_CL |