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dc.contributorSpringer-Verlages_CL
dc.contributor.authorBoehler, Annette [University Hospital Zurich,Zurich, Switzerland]es_CL
dc.contributor.authorRechsteiner, Thomas [University Hospital Zurich]es_CL
dc.contributor.authorBogdanova, Anna [University of Zurich]es_CL
dc.contributor.authorJelkmann, Wolfgang [Alemania. University of Luebeck]es_CL
dc.contributor.authorHofer, Markus [University Hospital Zurich]es_CL
dc.contributor.authorRawlings, Pablo [Chile. Universidad Mayor. Facultad de Medicina]es_CL
dc.date.accessioned2018-09-07T14:11:42Z
dc.date.available2018-09-07T14:11:42Z
dc.date.issued2009es_CL
dc.identifier.citationHeinicke, I., Boehler, A., Rechsteiner, T. et al. Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate. Eur J Appl Physiol (2009) 106: 599. https://doi.org/10.1007/s00421-009-1014-9es_CL
dc.identifier.issnISSN 1439-6319es_CL
dc.identifier.issnESSN 1439-6327es_CL
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007/s00421-009-1014-9.pdfes_CL
dc.identifier.urihttps://doi.org/10.1007/s00421-009-1014-9es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/2737
dc.description.abstractOxidative stress occurs at altitude, and physical exertion might enhance this stress. In the present study, we investigated the combined effects of exercise and moderate altitude on redox balance in ten endurance exercising biathletes, and five sedentary volunteers during a 6-week-stay at 2,800 m. As a marker for oxidative stress, hydrogen peroxide (H(2)O(2)) was analyzed by the biosensor measuring system Ecocheck, and 8-iso prostaglandin F2alpha (8-iso PGF2alpha) was determined by enzyme immunoassay in exhaled breath condensate (EBC). To determine the whole blood antioxidative capacity, we measured reduced glutathione (GSH) enzymatically using Ellman's reagent. Exercising athletes and sedentary volunteers showed increased levels of oxidative markers at moderate altitude, contrary to our expectations; there was no difference between both groups. Therefore, all subjects' data were pooled to examine the oxidative stress response exclusively due to altitude exposure. H(2)O(2) levels increased at altitude and remained elevated for 3 days after returning to sea level (p < or = 0.05). On the other hand, 8-iso PGF2alpha levels showed a tendency to increase at altitude, but declined immediately after returning to sea level (p < or = 0.001). Hypoxic exposure during the first day at altitude resulted in elevated GSH levels (p < or = 0.05), that decreased during prolonged sojourn at altitude (p < or = 0.001). In conclusion, a stay at moderate altitude for up to 6 weeks increases markers of oxidative stress in EBC independent of additional endurance training. Notably, this oxidative stress is still detectable 3 days upon return to sea level.es_CL
dc.description.sponsorshipEste trabajo fue financiado por Eidgenössische Sportkommission (ESK) des Bundesamtes für Sport (BASPO), Swiss National Science Foundation (3100A0-100214) y Fensterfabrik Albisrieden, Zurich, Switzerland (U. & G. Frei).es_CL
dc.format.extentARTÍCULO ORIGINALes_CL
dc.language.isoenes_CL
dc.publisherCIENCIASes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees_CL
dc.subjectFISIOLOGÍAes_CL
dc.titleModerate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensatees_CL
dc.typeArtículo o Paperes_CL
umayor.indizadorCOTes_CL
umayor.politicas.sherpa/romeoLicencia color: VERDE C/R (Se puede archivar el pre-print y el post-print o versión de editor/PDF, el autor no puede archivar la versión del editor/PDF)--Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares). Postcript: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares), Versión de editor/PDF: cross el autor no puede archivar la versión del editor/PDF, Condiciones generales: Author's pre-print on pre-print servers such as arXiv.org, Author's post-print on author's personal website immediately, Author's post-print on any open access repository after 12 months after publication, La versión de editor/PDF no puede utilizarse, La fuente editorial debe reconocerse, Debe ir enlazado a la versión de editor, Set phrase to accompany link to published version (see policy), Los artículos de algunas revistas pueden hacerse de acceso abierto mediante el pago de una tarifa adicional// Disponible en: http://www.sherpa.ac.uk/romeo/issn/1439-6319/es/es_CL
umayor.indexadoWOSes_CL
dc.identifier.doi10.1007/s00421-009-1014-9es_CL]
umayor.indicadores.wos-(cuartil)Q3es_CL
umayor.indicadores.scopus-(scimago-sjr)sin informaciónes_CL


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