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dc.contributorWileyes_CL
dc.contributor.authorAlvarez, Jaime [Chile. Universidad Mayor. Facultad de Ciencias]es_CL
dc.contributor.authorCourt, Felipe A. [Chile. Universidad Mayor. Facultad de Ciencias]es_CL
dc.date.accessioned2018-09-07T14:11:43Z
dc.date.available2018-09-07T14:11:43Z
dc.date.issued2016es_CL
dc.identifier.citationLópez‐Leal, R., Alvarez, J., & Court, F. A. (2016). Origin of axonal proteins: Is the axon‐schwann cell unit a functional syncytium?. Cytoskeleton, 73(10), 629-639.es_CL
dc.identifier.issnISSN 1949-3584es_CL
dc.identifier.issnESSN 1949-3592es_CL
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21319es_CL
dc.identifier.urihttps://doi.org/10.1002/cm.21319es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/2750
dc.description.abstractThe structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome the capacity of the cell body to supply the right protein species, to the right place, in the right time. In this context, a body of evidence indicates that glial cells support the axonal maintenance and regenerative responses by diverse mechanisms of intercellular communication. We showed recently that Schwann cells (SC) transfer ribosomes to axons and also enhance regeneration by means of extracellular vesicles known as exosomes that contain mRNAs, miRNAs and proteins. These findings strongly suggest that the nucleus of the SC supports the machinery for protein synthesis of the axon and participates in the specification of the phenotype of the underlying axon. That the genetic programs of many nuclei modulate the axoplasm on a local basis is akin to a syncytium but at variance with it, the nuclei belong to satellite cells. We propose that the SC-axon unit is a functional syncytium. This intercellular organization opens a novel understanding of the nervous system and a new avenue of research into its physiology and disorders.es_CL
dc.description.sponsorshipEste trabajo fue financiado por: Millennium Nucleus-P-07-011-F, FONDECYT 1150766, Ring Initiative-ACT1109, FONDAP-15150012, Canada-Israel Health Research initiative, Canadian Institutes of Health Research, Israel Science Foundation, International Development Research Centre y Canada and the Azrieli Foundation.es_CL
dc.format.extentARTÍCULO ORIGINALes_CL
dc.language.isoenes_CL
dc.publisherCIENCIASes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees_CL
dc.subjectCIENCIAS BIOLÓGICASes_CL
dc.titleOrigin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?es_CL
dc.typeArtículo o Paperes_CL
umayor.indizadorCOTes_CL
umayor.politicas.sherpa/romeoLicencia color: AMARILLO (Puede archivar el pre-print (ie la versión previa a la revisión por pares))-- Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares) Post-print del autor: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares) siempre que se cumplan las restricciones: 12 meses de embargo Versión de editor/PDF: cross el autor no puede archivar la versión del editor/PDF. Condiciones generales: Algunas revistas tienen políticas independientes, consultar directamente con cada revista, On author's personal website, institutional repositories, arXiv, AgEcon, PhilPapers, PubMed Central, RePEc or Social Science Research Network, Author's pre-print may not be updated with Publisher's Version/PDF, Author's pre-print must acknowledge acceptance for publication, No comercial, La versión de editor/PDF no puede utilizarse, Debe reconocerse la fuente de publicación con la cita, Must link to publisher version with set statement (see policy), If OnlineOpen is available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 12 months// Disponible en: http://www.sherpa.ac.uk/romeo/issn/1949-3584/es/es_CL
umayor.indexadoWOSes_CL
umayor.indexadoSCOPUSes_CL
dc.identifier.doi10.1002/cm.21319es_CL]
umayor.indicadores.wos-(cuartil)Q3es_CL
umayor.indicadores.scopus-(scimago-sjr)sin informaciónes_CL


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