| dc.contributor.author | Valdivia, Leonardo E. [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Krasnow, Anna M. | es_CL |
| dc.contributor.author | Ford, Marc C. | es_CL |
| dc.contributor.author | Wilson, Stephen W. | es_CL |
| dc.contributor.author | Attwell, David | es_CL |
| dc.date.accessioned | 2020-04-08T14:11:55Z | |
| dc.date.accessioned | 2020-04-13T18:12:33Z | |
| dc.date.available | 2020-04-08T14:11:55Z | |
| dc.date.available | 2020-04-13T18:12:33Z | |
| dc.date.issued | 2018 | es_CL |
| dc.identifier.citation | Krasnow, A. M., Ford, M. C., Valdivia, L. E., Wilson, S. W., & Attwell, D. (2018). Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature neuroscience, 21(1), 24-28. | es_CL |
| dc.identifier.issn | 1097-6256 | es_CL |
| dc.identifier.issn | 1546-1726 | es_CL |
| dc.identifier.uri | https://doi.org/10.1038/s41593-017-0031-y | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6089 | |
| dc.description.abstract | How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development. | es_CL |
| dc.description.sponsorship | Wellcome TrustWellcome Trust [099691/Z/12/Z]; EU Marie Curie FellowshipEuropean Union (EU) [623714]; Wellcome Trust Investigator AwardWellcome Trust [099222/Z/12/Z, 104682/Z/14/Z]; MRC Programme grantMedical Research Council UK (MRC) [MR/L003775/1] | es_CL |
| dc.description.sponsorship | We thank I.L. Arancibia-Carcamo, I. Bianco, E. Dreosti, V. Kyrargyri and W.T. Sherlock for comments, and we thank Fish Facility personnel for care of fish. This work was supported by a Wellcome Trust 4-year PhD studentship (099691/Z/12/Z) to A.M.K., an EU Marie Curie Fellowship (623714) to M.C.F., Wellcome Trust Investigator Awards to D.A. (099222/Z/12/Z) and S.W.W. (104682/Z/14/Z) and an MRC Programme grant (MR/L003775/1) to S.W.W. and G. Gestri. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | NATURE PUBLISHING GROUP | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Nat. Neurosci., ENE 2018. 21(1): p. 24-+ | |
| dc.subject | Neurosciences | es_CL |
| dc.title | Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | es_CL |
| umayor.politicas.sherpa/romeo | Green Accepted | es_CL |
| umayor.indexado | WOS:000423155800009 | es_CL |
| umayor.indexado | PMID: 29230052 | es_CL |
| dc.identifier.doi | DOI: 10.1038/s41593-017-0031-y | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 375 H | es_CL |