| dc.contributor.author | Vidal, Rene L. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile] | es_CL |
| dc.contributor.author | Rivera, Claudia A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile] | es_CL |
| dc.contributor.author | Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile] | es_CL |
| dc.contributor.author | Urra, Hery; Henriquez, Daniel R.; Canovas, José; Villarroel-Campos, David; Carreras-Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Alvarez-Rojas, Sebastián; Figueroa, Ricardo; Rodríguez, Diego A.; Couve, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic, Alvaro; González-Billault, Christian; Hetz, Claudio | es_CL |
| dc.date.accessioned | 2020-04-08T14:11:55Z | |
| dc.date.accessioned | 2020-04-13T18:12:34Z | |
| dc.date.available | 2020-04-08T14:11:55Z | |
| dc.date.available | 2020-04-13T18:12:34Z | |
| dc.date.issued | 2018 | es_CL |
| dc.identifier.citation | Urra, H., Henriquez, D. R., Cánovas, J., Villarroel-Campos, D., Carreras-Sureda, A., Pulgar, E., ... & Figueroa, R. (2018). IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nature cell biology, 20(8), 942-953. | es_CL |
| dc.identifier.issn | 1465-7392 | es_CL |
| dc.identifier.issn | 1476-4679 | es_CL |
| dc.identifier.uri | https://doi.org/10.1038/s41556-018-0141-0 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6094 | |
| dc.description.abstract | Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1 alpha. Filamin A is an actin crosslinking factor involved in cytoskeleton remodelling. We show that IRE1 alpha controls actin cytoskeleton dynamics and affects cell migration upstream of filamin A. The regulation of cytoskeleton dynamics by IRE1 alpha is independent of its canonical role as a UPR mediator, serving instead as a scaffold that recruits and regulates filamin A. Targeting IRE1 alpha expression in mice affected normal brain development, generating a phenotype resembling periventricular heterotopia, a disease linked to the loss of function of filamin A. IRE1 alpha also modulated cell movement and cytoskeleton dynamics in fly and zebrafish models. This study unveils an unanticipated biological function of IRE1 alpha in cell migration, whereby filamin A operates as an interphase between the UPR and the actin cytoskeleton. | es_CL |
| dc.description.sponsorship | FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [3160461, 1140549, 1180993, 1140325, 1150608, 1150766, 3160478, 3150113, 1140522]; Millennium InstituteTakeda Pharmaceutical Company Ltd [P09-015-F]; FONDAP [15150012, 15090007]; ECOS-CONICYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [170032]; PIA-CONICYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [ACT1401]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 Gm113188]; CONICYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [ACT1402]; European Commission RD MSCA-RISE [734749]; Michael J Fox Foundation for Parkinson's Research-Target Validation grant [9277]; FONDEF [ID16I10223, D11E1007]; US Office of Naval Research-Global (ONR-G) [N62909-16-1-2003]; US Air Force Office of Scientific ResearchUnited States Department of DefenseAir Force Office of Scientific Research (AFOSR) [FA9550-16-1-0384]; ALSRP Therapeutic Idea Award [AL150111]; Muscular Dystrophy AssociationMuscular Dystrophy Association [382453]; CONICYT-Brazil [441921/2016-7]; Toray Science FoundationToray Industries, Inc.; CONICYT fellowshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [21160967]; CONICYT research grant | es_CL |
| dc.description.sponsorship | We thank P. Walter for providing IRE1-3F6H-GFP cells and M. P. Sheetz for providing filamin A-deficient cells and expression vectors. In addition, we thank D. Calderwood and D. Iwamoto for providing IgG-like filamin A individual plasmids tagged with GFP or GST. We thank L. Leyton for providing phospho-specific anti-PKC antibodies. This work was funded by the following bodies: FONDECYT no. 3160461 (to H.U.), no. 1140549 and 1180993 (to C.H.), no. 1140325 (to C.G.-B.), no. 1150608 (to R.L.V.); no. 1150766 (to F.C.); no. 3160478 (to E.P.); no. 3150113 (to A. C-S.) and no. 1140522 (to A.G.); Millennium Institute No. P09-015-F (to C.H., A. C. and M. L. C.); FONDAP 15150012 (to C.H., F.C., C.G.-B. and M. L. C.); FONDAP 15090007 (to A.G.); ECOS-CONICYT 170032 (to C.H.); PIA-CONICYT ACT1401 (to A.G.); NIH R01 Gm113188 (L.Q.) and CONICYT ACT1402 (to M. L. C.). We also thank the following organizations: the European Commission R&D MSCA-RISE #734749; The Michael J Fox Foundation for Parkinson's Research-Target Validation grant No 9277; FONDEF ID16I10223; FONDEF D11E1007; the US Office of Naval Research-Global (ONR-G) N62909-16-1-2003; the US Air Force Office of Scientific Research FA9550-16-1-0384; ALSRP Therapeutic Idea Award AL150111; Muscular Dystrophy Association 382453; and CONICYT-Brazil 441921/2016-7 (to C.H.). T.I. is supported by the Toray Science Foundation. J. C., C. M. L (no. 21160967) and D.R.H. are doctoral fellows supported by a CONICYT fellowship and by a CONICYT research grant. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | NATURE PUBLISHING GROUP | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Nat. Cell Biol., AGO 2018. 20(8): p. 942-+ | |
| dc.subject | Cell Biology | es_CL |
| dc.title | IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | es_CL |
| umayor.politicas.sherpa/romeo | RoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000440057000013 | es_CL |
| umayor.indexado | PMID: 30013108 | es_CL |
| dc.identifier.doi | DOI: 10.1038/s41556-018-0141-0 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 337 H | es_CL |