| dc.contributor.author | Martínez, Gabriela [Univ Mayor, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Khatiwada, Sanjeev | es_CL |
| dc.contributor.author | Costa-Mattioli, Mauro | es_CL |
| dc.contributor.author | Hetz, Claudio | es_CL |
| dc.date.accessioned | 2020-04-08T14:11:55Z | |
| dc.date.accessioned | 2020-04-13T18:12:34Z | |
| dc.date.available | 2020-04-08T14:11:55Z | |
| dc.date.available | 2020-04-13T18:12:34Z | |
| dc.date.issued | 2018 | es_CL |
| dc.identifier.citation | Martínez, G., Khatiwada, S., Costa-Mattioli, M., & Hetz, C. (2018). ER proteostasis control of neuronal physiology and synaptic function. Trends in neurosciences, 41(9), 610-624. | es_CL |
| dc.identifier.issn | 0166-2236 | es_CL |
| dc.identifier.issn | 1878-108X | es_CL |
| dc.identifier.uri | https://doi.org/10.1016/j.tins.2018.05.009 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6096 | |
| dc.description.abstract | Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) serves as a fundamental pillar of the proteostasis network, and is emerging as a key compartment to sustain normal brain function. The unfolded protein response (UPR), the main mechanism that copes with ER stress, plays a central role in the quality control of many ion channels and receptors, in addition to crosstalk with signaling pathways that regulate connectivity, synapse formation, and neuronal plasticity. We provide here an overview of recent advances in the involvement of the UPR in maintaining neuronal proteostasis, and discuss its emerging role in brain development, neuronal physiology, and behavior, as well as the implications for neurodegenerative diseases involving cognitive decline. | es_CL |
| dc.description.sponsorship | US Office of Naval Research-Global (ONR-G) [N62909-16-1-2003]; Millennium InstituteTakeda Pharmaceutical Company Ltd [P09-015-F]; FONDEF [ID16I10223, D11E1007]; US Air Force Office of Scientific ResearchUnited States Department of DefenseAir Force Office of Scientific Research (AFOSR) [FA9550-16-1-0384]; CONICYT-Brazil [441921/2016-7]; Leading House for the Latin American Region seed money grant; FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [3150637, 1180186]; Muscular Dystrophy; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [NIMH 096816, NINDS 076708]; National Institutes of Health (Sammons Foundation) | es_CL |
| dc.description.sponsorship | This work was funded by US Office of Naval Research-Global (ONR-G) grant N62909-16-1-2003, Millennium Institute P09-015-F, FONDEF ID16I10223, US Air Force Office of Scientific Research FA9550-16-1-0384, CONICYT-Brazil 441921/2016-7, and a Leading House for the Latin American Region seed money grant (C.H.). We also thank FONDECYT 3150637 (GM). In addition, we are grateful for the support from FONDEF D11E1007, Muscular Dystrophy and FONDECYT 1180186 (C.H.), and for grants from the National Institutes of Health to M.C.M. (NIMH 096816, NINDS 076708, and the Sammons Foundation). | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | ELSEVIER SCIENCE LONDON | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Trends Neurosci., SEP 2018. 41(9): p. 610-624 | |
| dc.subject | Neurosciences | es_CL |
| dc.title | ER Proteostasis Control of Neuronal Physiology and Synaptic Function | es_CL |
| dc.type | Revisión | es_CL |
| umayor.facultad | CIENCIAS | es_CL |
| umayor.politicas.sherpa/romeo | RoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000442299100012 | es_CL |
| umayor.indexado | PMID: 29945734 | es_CL |
| dc.identifier.doi | DOI: 10.1016/j.tins.2018.05.009 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 269 H | es_CL |