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dc.contributor.authorCamarada, María Belén [Univ Mayor, Fac Ciencias, Ctr Nanotecnol Aplicada]es_CL
dc.contributor.authorJayakumar, Kumarasamyes_CL
dc.contributor.authorRajesh, Rajendiranes_CL
dc.contributor.authorVenkatesan, Rengarajanes_CL
dc.contributor.authorJu, Huangxianes_CL
dc.contributor.authorDharuman, Venkataramanes_CL
dc.contributor.authorWen, Yangpinges_CL
dc.date.accessioned2020-04-08T14:11:55Z
dc.date.accessioned2020-04-13T18:12:34Z
dc.date.available2020-04-08T14:11:55Z
dc.date.available2020-04-13T18:12:34Z
dc.date.issued2018es_CL
dc.identifier.citationJayakumar, K., Camarada, M. B., Rajesh, R., Venkatesan, R., Ju, H., Dharuman, V., & Wen, Y. (2018). Layer-by-layer assembled gold nanoparticles/lower-generation (Gn≤ 3) polyamidoamine dendrimers-grafted reduced graphene oxide nanohybrids with 3D fractal architecture for fast, ultra-trace, and label-free electrochemical gene nanobiosensors. Biosensors and Bioelectronics, 120, 55-63.es_CL
dc.identifier.issn0956-5663es_CL
dc.identifier.issn1873-4235es_CL
dc.identifier.urihttps://doi.org/10.1016/j.bios.2018.08.032es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/6098
dc.description.abstractThree layer-by-layer (LBL) assembled gold nanoparticles (AuNPs)/lower-generation (Gn <= 3) polyamidoamine dendrimer (PD) with reduced graphene oxide (rGO) as the core/mercaptopropinoic acid (MPA)/Au were successfully fabricated and employed as electrochemical gene nanobiosensing platforms with three-dimensional (3D) fractal nanoarchitecture for fast, ultra-trace determination of label-free DNA hybridization. Three Gn <= 3PD were initially grafted to graphite oxide (GO) via the covalent functionalization between amino terminals of PD and carboxyl terminals of GO where a concomitant reduction of GO, which were covalently linked onto MPA that was self-assembled onto Au substrate, and finally AuNPs were encapsulated onto GG1PD by strong physicochemical interaction between AuNPs and-OH of rGO in GG1PD, Their morphologies, structures, electrochemical properties, and gene nanobiosensing performances were characterized and evaluated. AuNPs/GG2PD-based probe displayed the best excellent structural stability, lowest mobility on solid surface with the increasing charge resistance, widest linear range (1.1 x 10(-6) - 1 x 10(-18)), and the lowest limit of detection (1.87 x 10(-19) M) in comparison with both AuNPs/GG1PD-based and AuNPs/GG3PD-based probes. This work will provide a new candidate for the development of metal nanoparticles functionalized PD with inorganic nonmetallic nanomaterials as cores with 3D fractal nanoarchitecture and promising electrochemical gene nanobiosensing platforms based on dendrimer-nanoinorganic hybrids with 3D nanoarchitectures and LBL assembly for fast and ultra-trace detection of label-free DNA hybridization with potential application in bioanalysis and medical diagnosis of genetic diseases.es_CL
dc.description.sponsorshipCSIR, Govt. of IndiaCouncil of Scientific & Industrial Research (CSIR) - India [03(1160)/10/EMR-II]; DST INSPIRE, Govt. of India [04/2015/000337]; Fondecyt Chile Project Regular [1180023]; Supercomputing infrastructure of NLHPC [ECM 02]; Outstanding Young Talent Program in Jiangxi Province [20171BCB23042]; NSFCNational Natural Science Foundation of China [51662014]es_CL
dc.description.sponsorshipThis work was supported by CSIR (03(1160)/10/EMR-II), and DST INSPIRE (04/2015/000337), Govt. of India and Fondecyt Chile Project Regular (1180023), Supercomputing infrastructure of NLHPC (ECM 02), Outstanding Young Talent Program in Jiangxi Province (20171BCB23042), and NSFC (51662014).es_CL
dc.language.isoenes_CL
dc.publisherELSEVIER ADVANCED TECHNOLOGYes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceBiosens. Bioelectron., NOV 2018. 120: p. 55-63
dc.subjectBiophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical; Electrochemistry; Nanoscience & Nanotechnologyes_CL
dc.titleLayer-by-layer assembled gold nanoparticles/lower-generation (Gn <= 3) polyamidoamine dendrimers-grafted reduced graphene oxide nanohybrids with 3D fractal architecture for fast, ultra-trace, and label-free electrochemical gene nanobiosensorses_CL
dc.typeArtículoes_CL
umayor.facultadCIENCIASes_CL
umayor.politicas.sherpa/romeoRoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.phpes_CL
umayor.indexadoWOS:000446288900008es_CL
umayor.indexadoPMID: 30145435es_CL
dc.identifier.doiDOI: 10.1016/j.bios.2018.08.032es_CL]
umayor.indicadores.wos-(cuartil)Q3es_CL
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 170 Hes_CL


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