| dc.contributor.author | González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim, Santiago, Chile] | es_CL |
| dc.contributor.author | Dossi, Camila G. | es_CL |
| dc.contributor.author | Romero, Nalda | es_CL |
| dc.contributor.author | Silva, David | es_CL |
| dc.contributor.author | Videla, Luis A. | es_CL |
| dc.contributor.author | Tapia, Gladys S. | es_CL |
| dc.date.accessioned | 2020-04-08T14:11:55Z | |
| dc.date.accessioned | 2020-04-13T18:12:54Z | |
| dc.date.available | 2020-04-08T14:11:55Z | |
| dc.date.available | 2020-04-13T18:12:54Z | |
| dc.date.issued | 2018 | es_CL |
| dc.identifier.citation | Dossi, C. G., González-Mañán, D., Romero, N., Silva, D., Videla, L. A., & Tapia, G. S. (2018). Anti-oxidative and anti-inflammatory effects of Rosa Mosqueta oil supplementation in rat liver ischemia-reperfusion. Food & function, 9(9), 4847-4857. | es_CL |
| dc.identifier.issn | 2042-6496 | es_CL |
| dc.identifier.issn | 2042-650X | es_CL |
| dc.identifier.uri | https://doi.org/10.1039/c8fo00969d | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6287 | |
| dc.description.abstract | Ischemia-reperfusion (IR) is a deleterious condition associated with liver transplantation or resection that involves pro-oxidant and pro-inflammatory mechanisms. Considering that Rosa Mosqueta (RM) oil composition is rich in protective components such as -linolenic acid (ALA) and tocopherols, we studied the effects of RM oil supplementation given prior to an IR protocol. Male Sprague-Dawley rats receiving RM oil (0.4 mL d(-1)) for 21 days were subjected to 1 h of ischemia followed by 20 h reperfusion. Parameters of liver injury (serum transaminases, histology), oxidative stress [liver contents of protein carbonyls, thiobarbituric acid reactants, Nrf2 activity and its target mRNA expression of heme oxygenase-1 (HO-1) and NADPH-quinone oxidoreductase-1 (NQO-1)] and inflammation [nuclear factor-B (NF-B) and its target mRNA expression of tumor necrosis factor- (TNF-) and interleukine-1 (IL-1)] were studied. RM oil increased liver ALA and its derived EPA and DHA fatty acids' contents, with enhancement in those of - and -tocopherols. IR induced inflammatory liver injury, with enhancement in serum transaminases, oxidative stress-related parameters with reduced Nrf2 signaling, and higher pro-inflammatory cytokines, indexes that were attenuated or abrogated by RM oil pretreatment. It is concluded that RM oil supplementation represents a novel non-invasive preconditioning strategy against liver injury induced by IR that has potential clinical applications in metabolic stress conditions. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | ROYAL SOC CHEMISTRY | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Food Funct., SEP 2018. 9(9): p. 4847-4857 | |
| dc.subject | Biochemistry & Molecular Biology; Food Science & Technology | es_CL |
| dc.title | Anti-oxidative and anti-inflammatory effects of Rosa Mosqueta oil supplementation in rat liver ischemia-reperfusion | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | es_CL |
| umayor.politicas.sherpa/romeo | RoMEO yellow journal (Puede archivar el pre-print (ie la versión previa a la revisión por pares). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000445216900030 | es_CL |
| umayor.indexado | PMID: 30140814 | es_CL |
| dc.identifier.doi | DOI: 10.1039/c8fo00969d | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q2 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 53 H | es_CL |