| dc.contributor.author | Riquelme, Erick [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Zhang, Yu; Zhang, Liangliang; Montiel, Maria; Zoltan, Michelle; Dong, Wenli; Quesada, Pompeyo; Sahin, Ismet; Chandra, Vidhi; San Lucas, Anthony; Scheet, Paul; Xu, Hanwen; Hanash, Samir M.; Feng, Lei; Burks, Jared K.; Do, Kim-Anh; Peterson, Christine B.; Nejman, Deborah; Tzeng, Ching-Wei D.; Kim, Michael P.; Sears, Cynthia L.; Ajami, Nadim; Petrosino, Joseph; Wood, Laura D.; Maitra, Anirban; Straussman, Ravid; Katz, Matthew; White, James Robert; Jenq, Robert; Wargo, Jennifer; McAllister, Florencia | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:28:49Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:28:49Z | |
| dc.date.issued | 2019 | es_CL |
| dc.identifier.citation | Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., ... & Scheet, P. (2019). Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell, 178(4), 795-806. | es_CL |
| dc.identifier.issn | 0092-8674 | es_CL |
| dc.identifier.issn | 1097-4172 | es_CL |
| dc.identifier.uri | https://doi.org/10.1016/j.cell.2019.07.008 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6322 | |
| dc.description.abstract | Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using 16S rRNA gene sequencing, we analyzed the tumor microbiome composition in PDAC patients with short-term survival (STS) and long-term survival (LTS). We found higher alpha-diversity in the tumor microbiome of LTS patients and identified an intra-tumoral microbiome signature (Pseudoxanthomonas-Streptomyces-Saccharopolyspora-Bacillus clausii) highly predictive of long-term survivorship in both discovery and validation cohorts. Through human-into-mice fecal microbiota transplantation (FMT) experiments from STS, LTS, or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration. Our study demonstrates that PDAC microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease. | es_CL |
| dc.description.sponsorship | American Gastroenterological Association Research Foundation; PanCAN/AACR Career Development Award [14-20-25-MCAL]; Emerson Collective Award; K12 Paul Calabresi Clinical Scholarship Award [K12CA088084-16A1]; MD Anderson Philanthropic Funds; Stand Up To Cancer-Lustgarten Foundation Pancreatic Cancer Interception Translational Cancer [SU2CAACR-DT25-17]; National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R25E CA056452]; MD Anderson's Cancer Center support grant [CA016672] | es_CL |
| dc.description.sponsorship | We thank Peter Davies for his scientific vision and feedback during the study conduction. F.M. has been funded by the American Gastroenterological Association Research Foundation, a PanCAN/AACR Career Development Award (14-20-25-MCAL), Emerson Collective Award, and K12 Paul Calabresi Clinical Scholarship Award (K12CA088084-16A1). A.M. and F.M. were funded by MD Anderson Philanthropic Funds and Stand Up To Cancer-Lustgarten Foundation Pancreatic Cancer Interception Translational Cancer (SU2CAACR-DT25-17) administered by the American Association for Cancer Research. E.R. acknowledges Becas Chile. P.Q. was supported by the National Cancer Institute (R25E CA056452) and a MD Anderson's Cancer Center support grant (CA016672). | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | CELL PRESS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Cell, AGO, 2019. 178(4): p. 795- | |
| dc.subject | Biochemistry & Molecular Biology; Cell Biology | es_CL |
| dc.title | Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO yellow journal (Puede archivar el pre-print (ie la versión previa a la revisión por pares). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000480292800008 | es_CL |
| umayor.indexado | PMID: 31398337 | es_CL |
| dc.identifier.doi | DOI: 10.1016/j.cell.2019.07.008 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 705 H | es_CL |