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  • Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury 

    Geronimo-Olvera, Cristian [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Girardi, Karina [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Necuñir-Ibarra, David [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Kumar Patel, Sandip; Bons, Joanna; Wright, Megan C.; Geschwind, Daniel; Hoke, Ahmet; Gómez-Sánchez, José A.; Schilling, Birgit; Rebolledo, Daniela L. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Campisi, Judith; Court, Felipe A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile] (Wiley-Blackwell, 2023-12-07)
    Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c-Jun transcription factor activation. ...
  • Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance 

    Santos, Nicolás [Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]; Valenzuela, Santiago; Segura, Camilo; Osorio-Román, Igor; Arrázola, Macarena S. [Centro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]; Panadero-Medianero, Concepción [Centro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]; Santana, Paula A.; Ahumada, Manuel [Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile] (Springer New York, 2023-10-17)
    Carbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties ...
  • Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome 

    Sanhueza, Sergio; Vidal, Mabel A.; Hernández, Mauricio A.; Henríquez-Beltrán, Mario E.; Cabrera, Camilo; Quiroga, Romina; Antilef, Bárbara E.; Aguilar, Kevin P.; Castillo, Daniela A.; Llerena, Faryd J.; Fraga Figueroa, Marco; Nazal, Mauricio; Castro, Eritson; Lagos, Paola; Moreno, Alexa; Lastra, Jaime J.; Gajardo, Jorge; Garcés, Pamela; Riffo, Benilde; Buchert, Jorge; Sanhueza, Rocío; Ormazábal, Valeska; Saldivia, Pablo; Vargas, Cristian; Nourdin, Guillermo; Koch, Elard; Zúñiga, Felipe A.; Lamperti, Liliana; Bustos, Paula; Guzmán-Gutiérrez, Enrique; Tapia, Claudio A.; Ferrada, Luciano; Cerda, Gustavo; Woehlbier, Ute [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Riquelme, Erick; Yuseff, María-Isabel; Muñoz Ramírez, Braulio A.; Lombardi, Giovanna; Gonzalo-Calvo, David de; Salomón, Carlos; Verdugo, Ricardo A.; Quiñones, Luis A.; Colombo, Alicia; Barría, María I.; Labarca, Gonzalo; Nova-Lamperti, Estefania (Frontiers Media S.A., 2023-10)
    Introduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of ...
  • Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction 

    Alvizi, Lucas; Nani, Diogo; Brito, Luciano Abreu; Kobayashi, Gerson Shigeru; Passos-Bueno, Maria Rita; Mayor, Roberto [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Nature Publishing Group, 2023-05-24)
    Gene-environment interactions are believed to play a role in multifactorial phenotypes, although poorly described mechanistically. Cleft lip/palate (CLP), the most common craniofacial malformation, has been associated with ...
  • Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network 

    Letelier, Joaquín [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile]; Buono, Lorena; Almuedo-Castillo, María; Zang, Jingjing; Mounieres, Constanza [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile]; González-Diaz, Sergio; Polvillo, Rocío; Sanabria-Reinoso, Estefanía; Corbacho, Jorge; Sousa-Ortega, Ana; del Corral, Ruth Diez; Neuhauss, Stephan C. F.; Martínez-Morales, Juan R. (eLIFE SCIENCES PUBL LTD, 2023-05-25)
    early function in progenitors' specification, and a later requirement for bipolar-cells fate determination. Despite their conserved expression patterns, it is currently unclear to which extent Vsx functions are also conserved ...
  • IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation 

    Gómora-García, Juan Carlos; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Pérez-Martínez, Xochitl; Massieu, Lourdes (SPRINGER NATURE, 2021-06-03)
    Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the ...
  • A global metagenomic map of urban microbiomes and antimicrobial resistance 

    Danko, D; Bezdan, D., Afshin, EE.; Ahsanuddin, Sofia; Bhattacharya, Chandrima; Butler, Daniel J.; Chng, Kern Rei; Donnellan, Daisy; Hecht, Jochen; Jackson, Katelyn; Kuchin, Katerina ; Karasikov, Mikhail; Lyons, Abigail; Mak, Lauren; Meleshko, Dmitry; Mustafa, Harun; Mutai, Beth; Neches, Russell Y.; Ng, Amanda; Nikolayeva, Olga; Nikolayeva, Tatyana; Png, Eileen; Ryon, Krista A.; Sanchez, Jorge L.; Shaaban, Heba; Sierra, Maria A.; Thomas, Dominique; Young, Ben; Abudayyeh, Omar O.; Alicea, Josue; Bhattacharyya, Malay; Blekhman, Ran; Castro-Nallar, Eduardo; Cañas, Ana M.; Chatziefthimiou, Aspassia D.; Crawford, Robert W.; De Filippis, Francesca; Deng, Youping; Desnues, Christelle; Dias-Neto, Emmanuel; Dybwad, Marius; Elhaik, Eran; Ercolini, Danilo; Frolova, Alina; Gankin, Dennis; Gootenberg, Jonathan S.; Graf, Alexandra B.; Green, David C.; Hajirasouliha, Iman; Hastings, Jaden J. A.; Hernandez, Mark; Jang, Soojin; Kahles, Andre; Kelly, Frank J.; Knights, Kaymisha; Kyrpides, Nikos C.; Labaj, Pawel P.; Lee, Patrick K. H.; Leung, Marcus H. Y.; Ljungdahl, Per O.; Mason-Buck, Gabriella; McGrath, Ken; Meydan, Cem; Mongodin, Emmanuel F.; Moraes, Milton Ozorio; Nagarajan, Niranjan; Nieto-Caballero, Marina; Noushmehr, Houtan; Oliveira, Manuela; Ossowski, Stephan; Osuolale, Olayinka O.; Ozcan, Orhan; Paez-Espino, David; Rascovan, Nicolas; Richard, Hugues; Ratsch, Gunnar; Schriml, Lynn M.; Semmler, Torsten; Sezerman, Osman U; Shi, Leming; Shi, Tieliu; Siam, Rania; Song, Le Huu ; Suzuki, Haruo; Court, Denise Syndercombe; Tighe, Scott W.; Tong, Xinzhao;Udekwu, Klas, I; Ugalde, Juan A.; Valentine, Brandon; Vassilev, Dimitar, I; Vayndorf, Elena M.; Velavan, Thirumalaisamy P.; Wu, Ju; Zambrano, Maria M. ; Zhu, Jifeng; Zhu, Sibo; Mason, Christopher E.; Iraola, Gregorio [Univ Mayor, Ctr Integrat Biol, Chile] (CELL PRESS, 2021-06-24)
    We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an ...
  • Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain 

    Gorostieta-Salas, Elisa; Moreno-Blas, Daniel; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cisneros, Bulmaro; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castro-Obregón, Susana (HINDAWI LTD, 2021-08-16)
    Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such ...
  • Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro 

    Farfán, Nicole; Sanhueza, Nicole [Univ Mayor Chile, Ctr Integrat Biol, Fac Sci, Chile]; Briones, Macarena; Burzio, Luis O; Burzio, Verónica A. (SOC BIOLGIA CHILE, 2021-10-19)
    Background The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, ...
  • Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts 

    Costa, Daniela; Levesque, Simón; Kumar, Nitin; Fresia, Pablo; Ferres, Ignacio; Lawley, Trevor D.; Iraola, Gregorio [Univ Mayor, Ctr Integrat Biol, Chile] (NATURE PORTFOLIO, 2021-02-09)
    Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which ...
  • Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study 

    Cuesta-Astroz, Yesid; Gischkow Rucatti, Guilherme [Univ Mayor, Fac Ciencias, Ctr Biol Integrat, Chile]; Murgas, Leandro [Univ Mayor, Lab Biol Redes, Ctr Genom & Bioinformat, Fac Ciencias, Chile]; SanMartin, Carol D.; Sanhueza, Mario [Univ Mayor, Fac Ciencias, Ctr Biol Integrat, Chile]; Martin, Alberto J. M. [Univ Mayor, Lab Biol Redes, Ctr Genom & Bioinformat, Fac Ciencias, Chile] (FRONTIERS MEDIA SA, 2021-07-28)
    Gene Regulatory Networks (GRNs) allow the study of regulation of gene expression of whole genomes. Among the most relevant advantages of using networks to depict this key process, there is the visual representation of large ...
  • Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells 

    Cruz, Pablo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Ahumada-Castro, Ulises [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Molgo, Jordi; Sauma, Daniela; Lovy, Alenka [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cárdenas, Cesar [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (MDPI, 2021-01)
    T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial ...
  • Levels of low-molecular-weight hyaluronan in periodontitis-treated patients and its immunostimulatory effects on CD4+ T lymphocytes 

    Castillo, Francisca; Monasterio, Gustavo; Ibarra, Juan; Guevara, José; Cafferata, Emilio A.; Carvajal, Paola; Vernal, Rolando; Vicencio, Emiliano [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cortez, Cristian [Univ Mayor, Fac Sci, Ctr Genom & Bioinformat, Chile] (SPRINGER HEIDELBERG, 2021-02-26)
    Objectives During periodontitis, chronic inflammation triggers soft tissue breakdown, and hyaluronan is degraded into fragments of low molecular weight (LMW-HA). This investigation aimed to elucidate whether LMW-HA fragments ...
  • CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity 1 of 1 CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity 

    Briceño, Pedro; Rivas-Yañez, Elizabeth; Rosemblatt, Mariana V.; Parra-Tello, Brian; Vargas, Leonardo; Lladser, Alvaro; Salazar-Onfray, Flavio; Elorza, Alvaro A.; Rosemblatt, Mario; Bono, Maria Rosa; Sauma, Daniela; Farias, Paula; Cardenas, Cesar [Univ Mayor, Ctr Integrat Biol, Chile] (FRONTIERS MEDIA SA, 2021-02-18)
    CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
  • In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells 

    Barrera-Avalos, Carlos; Diaz, Ximena; Madrid, Bastian; Michelson, Sofia A.; Robles-Planells, Claudia; Sanchez-Guerrero, Giselle; Ahumada, Viviana; Mella-Torres, Andrea; Rojo, Leonel E.; Imarai, Monica; Milla, Luis A.; Leiva-Salcedo, Elias; Fernandez, Ricardo; Escobar, Alejandro; Acuña-Castillo, Claudio; Murgas, Paola [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (HINDAWI LTD, 2021-03-14)
    Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific immune responses. Immunization strategies using whole dead cells from tumor tissue, containing ...
  • Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort 

    Rogers, Nicole K.; Farias, Gonzalo; Delgado, Carolina; Henriquez, Mauricio; Herrera, Luisa; Behrens, Maria; Arevalo, Nohela B. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castillo-Godoy, Daniela P. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Espinoza-Fuenzalida, Italo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; SanMartin, Carol D. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Escuela Tecnol Med, Escuela Biotecnol, Chile] (IOS PRESS, 2021-07-15)
    Background: Amyloid-beta peptide (A beta) deposition in Alzheimer's disease (AD) is due to an imbalance in its production/clearance rate. Ap is transported across the blood-brain barrier by LRP1 and P-gp as efflux transporters ...
  • Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence 

    Ahumada-Castro, Ulises [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Puebla-Huerta, Andrea [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cuevas-Espinoza, Victor [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lovy, Alenka [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cesar Cardenas, J. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (ELSEVIER, 2021-08-31)
    Cellular senescence generates a permanent cell cycle arrest, characterized by apoptosis resistance and a pro-inflammatory senescence-associated secretory phenotype (SASP). Physiologically, senescent cells promote tissue ...
  • In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes 

    Ahumada-Castro, Ulises [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Bustos, Galdo [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Silva-Pavez, Eduardo [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Puebla-Huerta, Andrea [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Lovy, Alenka [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Cardenas, Cesar [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile] (FRONTIERS MEDIA SA, 2021-03-22)
    In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol ...
  • P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis 

    Wisniewski, Laura; French, Vanessa; Lockwood, Nicola; Valdivia, Leonardo E. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Frankel, Paul (Nature Publishing Group, 2020-09)
    P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF ...
  • Metformin protects from oxaliplatin induced peripheral neuropathy in rats 

    Martinez, N W [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Sánchez, A.; Diaz, P.; Broekhuizen, R.; Godoy, J.; Mondaca, S.; Catenaccio, A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Macanas, P.; Nervi, B.; Calvo, M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Elsevier BV, 2020-08)
    Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients ...

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