| dc.contributor.author | César Cardenas, J. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Luke Wiseman, R. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Carreras-Sureda, Amado; Jana, Fabian; Urra, Hery; Duránd, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, María L.; Pihan, Philippe; van Vliet, Alexander R.; González-Quiroz, Matias; Torres, Angie K.; Tapia-Rojas, Cheril; Kerkhofs, Martijn; Vicente, Ruben; Kaufman, Randal J.; Inestrosa, Nibaldo C.; González-Billault, Christian; Agostinis, Patrizia; Bultynck, Geert; Kroemer, Guido; Hetz, Claudio | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:28:50Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:28:50Z | |
| dc.date.issued | 2019 | es_CL |
| dc.identifier.citation | Carreras-Sureda, A., Jaña, F., Urra, H., Durand, S., Mortenson, D. E., Sagredo, A., ... & Pihán, P. (2019). Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature cell biology, 21(6), 755-767. | es_CL |
| dc.identifier.issn | 1465-7392 | es_CL |
| dc.identifier.issn | 1476-4679 | es_CL |
| dc.identifier.uri | https://doi.org/10.1038/s41556-019-0329-y | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6324 | |
| dc.description.abstract | Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected function of the endoplasmic reticulum stress transducer IRE1 alpha as a structural determinant of MAMs that controls mitochondrial calcium uptake. IRE1 alpha deficiency resulted in marked alterations in mitochondrial physiology and energy metabolism under resting conditions. IRE1 alpha determined the distribution of inositol-1,4,5-trisphosphate receptors at MAMs by operating as a scaffold. Using mutagenesis analysis, we separated the housekeeping activity of IRE1 alpha at MAMs from its canonical role in the unfolded protein response. These observations were validated in vivo in the liver of IRE1 alpha conditional knockout mice, revealing broad implications for cellular metabolism. Our results support an alternative function of IRE1 alpha in orchestrating the communication between the endoplasmic reticulum and mitochondria to sustain bioenergetics. | es_CL |
| dc.description.sponsorship | FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [1140549, 1160332, FONDAP15150012, 11180825, 3150113, 3140355, 3140458, 11170291, 3180427, 3190738, 11170546, 1150766]; FONDAP [15150012]; Millennium InstituteTakeda Pharmaceutical Company Ltd [P09-015-F]; European Commission RD MSCA-RISE [734749]; Michael J. Fox Foundation [9277]; FONDEF [ID16I10223, D11E1007]; US Office of Naval Research-GlobalOffice of Naval Research [N62909-16-1-2003]; US Air Force Office of Scientific ResearchUnited States Department of DefenseAir Force Office of Scientific Research (AFOSR) [FA9550-16-1-0384]; ALSRP Therapeutic Idea Award [AL150111]; Muscular Dystrophy AssociationMuscular Dystrophy Association [382453]; Seed grant Leading House for the Latin American Region, Switzerland; CONICYT-Brazil [441921/2016-7]; Spanish Ministry of Economy and Competitiveness [SAF2014-52228-R]; Unidad de Excelencia Maria de Maeztu - MINECO [MDM-2014-0370]; Fundacio la Marato de TV3 [20134030]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [NS095892]; EMBOEuropean Molecular Biology Organization (EMBO) [ASTF 385-2016]; CONICYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [PAI 77170091, PCHA/Doctorado Nacional/2016-21160232]; Research Council KU LeuvenKU Leuven [OT14/101]; Research Foundation - Flanders (FWO)FWO [G. 0C91.14N, G. 0A34.16N]; FWO Scientific Research Community"Ca2+ signaling in health, disease and therapy"FWO [W0.019.17]; FWOFWO [G049817N, G076617N]; KU LeuvenKU Leuven [C16/15/073]; FWO doctorate fellowship; European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grantEuropean Union (EU) [675448]; George E. Hewitt Foundation; Ligue contre le CancerLigue nationale contre le cancer; Agence National de la RechercheFrench National Research Agency (ANR); ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancerFondation ARC pour la Recherche sur le CancerAustralian Research Council; Canceropole Ile-de-FranceRegion Ile-de-France; Chancelerie des universites de Paris (Legs Poix); European Research Area Network on Cardiovascular Diseases (MINOTAUR); European Union Horizon 2020 Project Oncobiome; Fondation Carrefour; High-end Foreign Expert Program in China [GDW20171100085]; Institut National du CancerInstitut National du Cancer (INCA) France; Inserm (HTE); Institut Universitaire de France; LeDucq FoundationLeducq Foundation; LabEx Immuno-Oncology; RHU Torino Lumiere; Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination; SIRIC Cancer Research and Personalized Medicine; Fondation pour la Recherche MedicaleFondation pour la Recherche Medicale; Gustave Roussy Odyssea; [R01DK113171]; [R01CA198103]; [R01DK103185] | es_CL |
| dc.description.sponsorship | We thank S. Lavandero, D. Rojas-Rivera and M. Chiong for initial feedback in this project and for sharing reagents, T. Iwawaki for providing IRE1 alpha null animals and L. Qi for providing IRE1 alpha mutant constructs, G. Hajnoczky for MAM linker constructs, T. Cali and M. Brini for the SPLICS constructs, D. Ron for providing IRE1 alpha null MEFs, J. Ponce for animal care, and N. Bossut, F. Aprahamian, A. Florizoone, M. Crabbe, K. Welkenhuyzen, C. Villablanca, T. Vervliet and T. Luyten for their support. This work was funded by FONDECYT 1140549, FONDAP program 15150012, the Millennium Institute P09-015-F and the European Commission R&D MSCA-RISE 734749 (to C.H.); the Michael J. Fox Foundation for Parkinson's Research target validation grant number 9277, FONDEF ID16I10223, FONDEF D11E1007, US Office of Naval Research-Global N62909-16-1-2003, US Air Force Office of Scientific Research FA9550-16-1-0384, ALSRP Therapeutic Idea Award AL150111, Muscular Dystrophy Association 382453, Seed grant Leading House for the Latin American Region, Switzerland and CONICYT-Brazil 441921/2016-7 (to C.H.), FONDECYT 1160332 and FONDAP15150012 (to J.C.C.); the Spanish Ministry of Economy and Competitiveness SAF2014-52228-R, Unidad de Excelencia Maria de Maeztu, funded by the MINECO (ref: MDM-2014-0370) and Fundacio la Marato de TV3 20134030 (to R.V.); NIH NS095892 (to R.L.W.); FONDECYT 11180825 (to H.U.); FONDECYT 3150113 and EMBO ASTF 385-2016 (to A.C.-S.); FONDECYT 3140355 (to E.R.-F.); FONDECYT 3140458 and 11170291 (to F. J.); FONDECYT 3180427 (to Y. H.); FONDECYT 3190738 (to A.S.-C.); FONDECYT 11170546 and CONICYT PAI 77170091 (to C.T.-R.); R01DK113171, R01CA198103 and R01DK103185 (to R.J.K.); FONDECYT 1150766 (to F.A.C.); the Research Council KU Leuven grant OT14/101 (to G. B.); the Research Foundation - Flanders (FWO) G. 0C91.14N, G. 0A34.16N and the FWO Scientific Research Community"Ca<SUP>2+</SUP> signaling in health, disease and therapy"W0.019.17 (to G.B.); FWO (G049817N, G076617N) and KU Leuven (C16/15/073) (to P.A.); a FWO doctorate fellowship (to M.K.); the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 675448 (to M.L.S.); CONICYT fellowship PCHA/Doctorado Nacional/2016-21160232 (to M.G.-Q.); the George E. Hewitt Foundation for a postdoctoral fellowship (to D.E.M.); Ligue contre le Cancer (equipe labellisee); Agence National de la Recherche - Projets blancs; under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer; Canceropole Ile-de-France; Chancelerie des universites de Paris (Legs Poix), Fondation pour la Recherche Medicale; a donation from Elior; the European Research Area Network on Cardiovascular Diseases (MINOTAUR), Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome; Fondation Carrefour; High-end Foreign Expert Program in China (GDW20171100085); Institut National du Cancer; Inserm (HTE); Institut Universitaire de France; LeDucq Foundation; the LabEx Immuno-Oncology; the RHU Torino Lumiere; the Seerave Foundation; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination; and the SIRIC Cancer Research and Personalized Medicine (to G.K.). | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | NATURE PUBLISHING GROUP | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Nat. Cell Biol., JUN, 2019. 21(6): p. 755- | |
| dc.subject | Cell Biology | es_CL |
| dc.title | Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO yellow journal (Puede archivar el pre-print (ie la versión previa a la revisión por pares). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000470080100012 | es_CL |
| umayor.indexado | PMID: 31110288 | es_CL |
| dc.identifier.doi | DOI: 10.1038/s41556-019-0329-y | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 337 H | es_CL |