| dc.contributor.author | Guzmán-Lastra, Francisca [Univ Mayor, Fac Ciencias] | es_CL |
| dc.contributor.author | Daddi-Moussa-Ider, Abdallah | es_CL |
| dc.contributor.author | Goh, Segun | es_CL |
| dc.contributor.author | Liebchen, Benno | es_CL |
| dc.contributor.author | Hoell, Christian | es_CL |
| dc.contributor.author | Mathijssen, Arnold J. T. M. | es_CL |
| dc.contributor.author | Scholz, Christian | es_CL |
| dc.contributor.author | Menzel, Andreas M. | es_CL |
| dc.contributor.author | Loewen, Hartmut | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:28:51Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:28:51Z | |
| dc.date.issued | 2019 | es_CL |
| dc.identifier.citation | Daddi-Moussa-Ider, A., Goh, S., Liebchen, B., Hoell, C., Mathijssen, A. J., Guzmán-Lastra, F., ... & Löwen, H. (2019). Membrane penetration and trapping of an active particle. The Journal of chemical physics, 150(6), 064906. | es_CL |
| dc.identifier.issn | 0021-9606 | es_CL |
| dc.identifier.issn | 1089-7690 | es_CL |
| dc.identifier.uri | https://doi.org/10.1063/1.5080807 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6334 | |
| dc.description.abstract | The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the particles can pass through cell membranes via passive endocytosis or by active penetration to reach a target cellular compartment or organelle. In this manuscript, we develop a simple model to describe the interaction of a self-driven spherical particle (moving through an effective constant active force) with a minimal membrane system, allowing for both penetration and trapping. We numerically calculate the state diagram of this system, the membrane shape, and its dynamics. In this context, we show that the active particle may either get trapped near the membrane or penetrate through it, where the membrane can either be permanently destroyed or recover its initial shape by self-healing. Additionally, we systematically derive a continuum description allowing us to accurately predict most of our results analytically. This analytical theory helps in identifying the generic aspects of our model, suggesting that most of its ingredients should apply to a broad range of membranes, from simple model systems composed of magnetic microparticles to lipid bilayers. Our results might be useful to predict the mechanical properties of synthetic minimal membranes. | es_CL |
| dc.description.sponsorship | DFG (Deutsche Forschungsgemeinschaft)German Research Foundation (DFG) [DA 2107/1-1, SCHO 1700/1-1, ME 3571/2-2, LO 418/16-3]; Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Human Frontier Science Program OrganizationHuman Frontier Science Program [HFSPO-LT001670/2017]; Millennium Nucleus"Physics of Active Matter"of the Millennium Scientific Initiative of the Ministry of Economy, Development and Tourism, Chile | es_CL |
| dc.description.sponsorship | A.D.M.I., A.M.M., and H.L. thank Joachim Clement for a stimulating discussion. The authors are indebted to Maciej Lisicki and Shang Yik Reigh for helpful comments and suggestions, and gratefully acknowledge support from the DFG (Deutsche Forschungsgemeinschaft) through the Project Nos. DA 2107/1-1, SCHO 1700/1-1, ME 3571/2-2, and LO 418/16-3. S.G. gratefully acknowledges funding from the Alexander von Humboldt Foundation. The work of A.J.T.M.M. was supported by a cross-disciplinary fellowship from the Human Frontier Science Program Organization (No. HFSPO-LT001670/2017). F.G.-L. acknowledges support from the Millennium Nucleus"Physics of Active Matter"of the Millennium Scientific Initiative of the Ministry of Economy, Development and Tourism, Chile. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | AMER INST PHYSICS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | J. Chem. Phys., FEB, 2019. 150(6) | |
| dc.subject | Chemistry, Physical; Physics, Atomic, Molecular & Chemical | es_CL |
| dc.title | Membrane penetration and trapping of an active particle | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000458879800049 | es_CL |
| umayor.indexado | PMID: 30770004 | es_CL |
| dc.identifier.doi | DOI: 10.1063/1.5080807 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q2 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 314 H | es_CL |