| dc.contributor.author | Andrade, David C. [Univ Mayor, Ctr Invest Fisiol Ejercicio, Santiago, Chile] | es_CL |
| dc.contributor.author | Toledo, Camilo; Díaz, Hugo S.; Lucero, Claudia; Arce-Alvarez, Alexis; Oliveira, Luiz M.; Takakura, Ana C.; Moreira, Thiago S.; Schultz, Harold D.; Marcus, Noah J.; Alcayaga, Julio; Del Rio, Rodrigo | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:28:52Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:28:52Z | |
| dc.date.issued | 2019 | es_CL |
| dc.identifier.citation | Andrade, D. C., Toledo, C., Díaz, H. S., Lucero, C., Arce-Álvarez, A., Oliveira, L. M., ... & Alcayaga, J. (2019). Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure. Clinical Science, 133(3), 393-405. | es_CL |
| dc.identifier.issn | 0143-5221 | es_CL |
| dc.identifier.issn | 1470-8736 | es_CL |
| dc.identifier.uri | https://doi.org/10.1042/CS20180589 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6348 | |
| dc.description.abstract | Activation of the sympathetic nervous system is a hallmark of heart failure (HF) and is positively correlated with disease progression. Catecholaminergic (C1) neurons located in the rostral ventrolateral medulla (RVLM) are known to modulate sympathetic outflow and are hyperactivated in volume overload HF. However, there is no conclusive evidence showing a contribution of RVLM-C1 neurons to the development of cardiac dysfunction in the setting of HF. Therefore, the aim of this study was to determine the role of RVLM-C1 neurons in cardiac autonomic control and deterioration of cardiac function in HF rats. A surgical arteriovenous shunt was created in adult male Sprague-Dawley rats to induce HF. RVLM-C1 neurons were selectively ablated using cell-specific immunotoxin (dopamine-beta hydroxylase saporin [D beta H-SAP]) and measures of cardiac autonomic tone, function, and arrhythmia incidence were evaluated. Cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction were present in HF rats and improved after D beta H-SAP toxin treatment. Most importantly, the progressive decline in fractional shortening observed in HF rats was reduced by D beta H-SAP toxin. Our results unveil a pivotal role played by RVLM-C1 neurons in cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction in volume overload-induced HF. | es_CL |
| dc.description.sponsorship | FONDECYT from the National Fund for Scientific and Technological Development of Chile [1180172]; Sao Paulo Research Foundation [FAPESP]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/23281-3, 2015/23376-1] | es_CL |
| dc.description.sponsorship | This work was supported by FONDECYT [grant number: 1180172] from the National Fund for Scientific and Technological Development of Chile. This work was also supported by the Sao Paulo Research Foundation [FAPESP; grants numbers: 2016/23281-3 to ACT and 2015/23376-1 to TSM]. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | PORTLAND PRESS LTD | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Clin. Sci., FEB, 2019. 133(3): p. 393-405 | |
| dc.subject | Medicine, Research & Experimental | es_CL |
| dc.title | Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO white journal (El archivo no está formalmente admitido). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000461204200001 | es_CL |
| umayor.indexado | PMID: 30626730 | es_CL |
| dc.identifier.doi | DOI: 10.1042/CS20180589 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 126 H | es_CL |