| dc.contributor.author | Silva-Pavez, Eduardo [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile] | es_CL |
| dc.contributor.author | Ahumada-Castro, Ulises [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile] | es_CL |
| dc.contributor.author | Lovy, Alenka | es_CL |
| dc.contributor.author | Pardo, Evelyn | es_CL |
| dc.contributor.author | Molgo, Jordi | es_CL |
| dc.contributor.author | Cardenas, César | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:37:34Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:37:34Z | |
| dc.date.issued | 2019 | es_CL |
| dc.identifier.citation | Ahumada-Castro, U., Silva-Pavez, E., Lovy, A., Pardo, E., Molgό, J., & Cárdenas, C. (2019). MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy, 15(2), 358-361. | es_CL |
| dc.identifier.issn | 1554-8627 | es_CL |
| dc.identifier.issn | 1554-8635 | es_CL |
| dc.identifier.uri | https://doi.org/10.1080/15548627.2018.1537769 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6350 | |
| dc.description.abstract | The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent AMPK-dependent macroautophagic/autophagic flux, which is not sufficient to reestablish the metabolic and energetic homeostasis in cancer cells. Here, we propose that upon ER-mitochondrial Ca2+ transfer inhibition, AMPK present at the mitochondria-associated membranes (MAMs) activate localized autophagy via BECN1 (beclin 1). This local response could prevent the proper interorganelle communication that would allow the autophagy-derived metabolites to reach the necessary anabolic pathways to maintain mitochondrial function and cellular homeostasis. | es_CL |
| dc.description.sponsorship | FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [1160332]; CONICYT/FONDAPComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDAP [15150012]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P30NS047243] | es_CL |
| dc.description.sponsorship | This work was supported by FONDECYT grant #1160332 (CC), CONICYT/FONDAP #15150012 (CC) and NIH P30NS047243 (AL). | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | TAYLOR & FRANCIS INC | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Autophagy, FEB, 2019. 15(2): p. 358-361 | |
| dc.subject | Cell Biology | es_CL |
| dc.title | MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | Green Published | es_CL |
| umayor.indexado | WOS:000454087000014 | es_CL |
| umayor.indexado | PMID: 30351219 | es_CL |
| dc.identifier.doi | DOI: 10.1080/15548627.2018.1537769 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 121 H | es_CL |